C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NLR family, CARD domain containing 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000091106 NLRC4 9606 - 2:32224453-32265854 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000342905 NLRC4-003 32224455-32265732 protein_coding
  ENST00000360906 NLRC4-002 32224453-32265732 protein_coding
  ENST00000402280 NLRC4-004 32224454-32264880 protein_coding
  ENST00000404025 NLRC4-001 32224456-32265854 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000342905ENST00000360906ENST00000402280ENST00000404025
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000342905 0.316±0.00 0.942±0.00 0.035±0.00 0.199±0.00 0.204±0.00 N/A N/A 0.327±0.05 N/A 0.376±0.00 N/A N/A N/A
ENST00000360906 0.281±0.00 N/A N/A N/A 0.344±0.00 0.178±0.00 0.408±0.00 0.235±0.07 N/A 0.412±0.00 0.215±0.08 0.250±0.01 0.194±0.09
ENST00000402280 N/A N/A N/A 0.083±0.00 0.495±0.00 N/A N/A N/A 0.194±0.14 1.798±0.00 0.225±0.00 0.665±0.19 N/A
ENST00000404025 0.368±0.00 0.111±0.00 N/A N/A N/A N/A 0.123±0.00 N/A 0.243±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000MX CIL_0000MX_0001 CGP 2:32165841-32265854
CIL_0000MY CIL_0000MY_0001 CGP 2:32224453-32316594

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 TAS magnesium ion binding
GO:0002218 ISS activation of innate immune response
GO:0005515 IPI protein binding
GO:0005524 IDA ATP binding
GO:0005622 NAS intracellular
GO:0005829 ISS cytosol
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 ISS inflammatory response
GO:0016045 IDA detection of bacterium
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042742 IDA defense response to bacterium
GO:0042802 IPI identical protein binding
GO:0042803 IDA protein homodimerization activity
GO:0042981 IEA regulation of apoptotic process
GO:0043065 IDA positive regulation of apoptotic process
GO:0043281 IEA regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 TAS innate immune response
GO:0050702 IDA interleukin-1 beta secretion
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051260 ISS protein homooligomerization
GO:0070269 ISS pyroptosis
GO:0072557 ISS IPAF inflammasome complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000039193 Nlrc4 NLR family, CARD domain containing 4 protein_coding Mus_musculus

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