C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mevalonate kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000041939 Mvk 10090 + 5:114444269-114460591 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000043760 Mvk-001 114444280-114460591 protein_coding
  ENSMUST00000112239 Mvk-005 114444286-114460477 protein_coding
  ENSMUST00000124260 Mvk-004 114444303-114453096 retained_intron
  ENSMUST00000125120 Mvk-002 114444294-114460584 retained_intron
  ENSMUST00000125650 Mvk-007 114444303-114455483 protein_coding
  ENSMUST00000137167 Mvk-003 114444269-114453149 retained_intron
  ENSMUST00000139420 Mvk-006 114452420-114460572 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000043760ENSMUST00000112239ENSMUST00000125120ENSMUST00000125650ENSMUST00000137167
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000043760 12.365±5.87 12.355±3.69 11.170±3.17 10.803±1.39 9.298±4.60 9.765±4.93 1.881±1.04 4.064±0.78 5.592±2.15 13.147±3.81 1.782±0.56 8.937±4.07 7.888±3.32 2.519±0.49
ENSMUST00000112239 6.890±1.82 12.178±2.14 2.849±0.00 6.857±0.49 4.605±1.52 7.581±1.27 0.704±0.19 3.296±0.63 5.508±2.29 6.019±0.63 0.793±0.32 8.421±2.21 4.053±1.54 1.628±0.22
ENSMUST00000125120 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.728±0.00 0.654±0.00 N/A
ENSMUST00000125650 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.887±0.30 4.650±0.00 N/A
ENSMUST00000137167 N/A N/A N/A 7.153±0.00 1.717±0.00 N/A N/A N/A N/A N/A N/A 7.295±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001GN CIL_0001GN_0003 CGP 5:114431034-114460591
CIL_0001JK CIL_0001JK_0003 CGP 5:114444269-114613220

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004496 IDA mevalonate kinase activity
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005829 IEA cytosol
GO:0006695 IEA cholesterol biosynthetic process
GO:0008299 IEA isoprenoid biosynthetic process
GO:0016310 IEA phosphorylation
GO:0019287 IEA isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0042802 IEA identical protein binding
GO:0050728 IEA negative regulation of inflammatory response
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004130 mvk mevalonate kinase protein_coding Danio_rerio
ENSG00000110921 MVK mevalonate kinase protein_coding Homo_sapiens

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