C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mevalonate kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000110921 MVK 9606 + 12:109573255-109598117 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000228510 MVK-001 109573812-109597266 protein_coding
  ENST00000392727 MVK-003 109573837-109597261 protein_coding
  ENST00000447878 MVK-004 109573793-109597236 nonsense_mediated_decay
  ENST00000535044 MVK-010 109573341-109586098 processed_transcript
  ENST00000537237 MVK-002 109573814-109596581 nonsense_mediated_decay
  ENST00000539335 MVK-006 109573255-109581535 protein_coding
  ENST00000539575 MVK-201 109574807-109598117 protein_coding
  ENST00000539696 MVK-009 109573805-109596677 protein_coding
  ENST00000540353 MVK-005 109587861-109597262 retained_intron
  ENST00000545516 MVK-011 109581479-109587099 retained_intron
  ENST00000545774 MVK-012 109573832-109587069 nonsense_mediated_decay
  ENST00000546277 MVK-007 109573302-109586096 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000228510ENST00000392727ENST00000447878ENST00000539335ENST00000540353ENST00000546277
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000228510 N/A 4.891±0.00 N/A 0.890±0.00 N/A 1.222±0.00 N/A 11.505±8.10 24.251±0.00 2.768±0.00 1.981±0.00 13.747±3.33 5.862±1.20 31.274±20.86
ENST00000392727 N/A N/A N/A N/A 0.572±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000447878 3.740±0.00 N/A N/A 11.259±0.00 N/A 2.398±0.00 N/A N/A 0.548±0.00 N/A 2.783±0.00 N/A 4.135±0.00 9.152±0.00
ENST00000539335 N/A N/A N/A N/A N/A N/A N/A N/A 1.675±0.00 N/A N/A N/A N/A N/A
ENST00000540353 N/A N/A 0.203±0.00 N/A 0.328±0.00 N/A N/A N/A N/A 0.499±0.00 N/A N/A N/A N/A
ENST00000546277 N/A N/A N/A N/A N/A N/A 1.231±0.00 7.871±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000401 CIL_000401_0001 CGP 12:109477402-109573874
CIL_0001GN CIL_0001GN_0002 CGP 12:109553737-109598117
CIL_0001JK CIL_0001JK_0002 CGP 12:109573255-109770507

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004496 IMP:IEA mevalonate kinase activity
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005829 IDA cytosol
GO:0006695 IDA cholesterol biosynthetic process
GO:0008299 IEA:IDA isoprenoid biosynthetic process
GO:0016310 IEA phosphorylation
GO:0019287 IEA isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0042802 IPI identical protein binding
GO:0044281 TAS small molecule metabolic process
GO:0050728 IMP negative regulation of inflammatory response
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004130 mvk mevalonate kinase protein_coding Danio_rerio
ENSMUSG00000041939 Mvk mevalonate kinase protein_coding Mus_musculus

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