C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000042228 Lyn 10090 + 4:3678115-3813122 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000041377 Lyn-001 3678115-3791613 protein_coding
  ENSMUST00000103010 Lyn-002 3678127-3791612 protein_coding
  ENSMUST00000137943 Lyn-004 3756457-3813122 processed_transcript
  ENSMUST00000145083 Lyn-003 3678130-3739176 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000041377ENSMUST00000103010ENSMUST00000137943
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000041377 3.595±0.36 N/A 3.102±0.77 0.925±0.67 4.964±2.77 3.558±0.00 1.647±0.55 1.819±0.48 4.544±2.89 7.989±0.58 0.880±0.27 3.676±1.28 3.837±1.69 0.244±0.01
ENSMUST00000103010 4.868±0.65 5.322±0.82 1.805±0.12 0.546±0.27 6.977±2.37 4.896±0.54 2.107±0.29 3.417±0.67 3.312±1.15 13.060±2.19 0.434±0.24 3.266±1.32 1.893±0.47 0.170±0.10
ENSMUST00000137943 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.984±0.19 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00009D CIL_00009D_0002 CGP 4:3574875-3813122
CIL_0001U6 CIL_0001U6_0002 CGP 4:3678115-3835665

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001782 IMP B cell homeostasis
GO:0001817 IMP regulation of cytokine production
GO:0001933 IMP negative regulation of protein phosphorylation
GO:0002431 IMP Fc receptor mediated stimulatory signaling pathway
GO:0002513 IMP tolerance induction to self antigen
GO:0002553 IEA histamine secretion by mast cell
GO:0002576 IMP platelet degranulation
GO:0002762 IMP negative regulation of myeloid leukocyte differentiation
GO:0002768 IMP immune response-regulating cell surface receptor signaling pathway
GO:0002774 IMP Fc receptor mediated inhibitory signaling pathway
GO:0002902 IMP regulation of B cell apoptotic process
GO:0004672 IDA protein kinase activity
GO:0004713 IDA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005102 IEA receptor binding
GO:0005128 TAS erythropoietin receptor binding
GO:0005161 IEA platelet-derived growth factor receptor binding
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005758 IEA mitochondrial intermembrane space
GO:0005794 IEA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0006991 IEA response to sterol depletion
GO:0007165 TAS signal transduction
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 IMP negative regulation of cell proliferation
GO:0009636 IEA response to toxic substance
GO:0009725 IDA response to hormone
GO:0009743 IEA response to carbohydrate
GO:0010976 IEA positive regulation of neuron projection development
GO:0014003 IEA oligodendrocyte development
GO:0014069 IEA postsynaptic density
GO:0014070 IEA response to organic cyclic compound
GO:0016020 IEA membrane
GO:0017124 IPI SH3 domain binding
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019899 IEA enzyme binding
GO:0030061 IEA mitochondrial crista
GO:0030097 IMP hemopoiesis
GO:0030218 IMP erythrocyte differentiation
GO:0030335 IMP positive regulation of cell migration
GO:0030889 IMP negative regulation of B cell proliferation
GO:0031175 IMP neuron projection development
GO:0031625 IEA ubiquitin protein ligase binding
GO:0031663 IMP lipopolysaccharide-mediated signaling pathway
GO:0031668 IEA cellular response to extracellular stimulus
GO:0031966 IEA mitochondrial membrane
GO:0032403 IPI protein complex binding
GO:0032868 IEA response to insulin
GO:0033003 IMP regulation of mast cell activation
GO:0033628 IEA regulation of cell adhesion mediated by integrin
GO:0034136 IMP negative regulation of toll-like receptor 2 signaling pathway
GO:0034144 IMP negative regulation of toll-like receptor 4 signaling pathway
GO:0034605 IEA cellular response to heat
GO:0034666 IEA integrin alpha2-beta1 complex
GO:0035556 IDA intracellular signal transduction
GO:0042327 IEA positive regulation of phosphorylation
GO:0042493 IEA response to drug
GO:0042531 IMP positive regulation of tyrosine phosphorylation of STAT protein
GO:0042541 TAS hemoglobin biosynthetic process
GO:0042629 IEA mast cell granule
GO:0043200 IEA response to amino acid
GO:0043208 IEA glycosphingolipid binding
GO:0043304 IMP regulation of mast cell degranulation
GO:0043407 IMP negative regulation of MAP kinase activity
GO:0043434 IEA response to peptide hormone
GO:0043552 IMP positive regulation of phosphatidylinositol 3-kinase activity
GO:0044325 IEA ion channel binding
GO:0045087 IEA innate immune response
GO:0045121 IEA membrane raft
GO:0045646 IMP regulation of erythrocyte differentiation
GO:0046777 IDA protein autophosphorylation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048678 IEA response to axon injury
GO:0050663 IEA cytokine secretion
GO:0050707 IMP regulation of cytokine secretion
GO:0050727 IMP regulation of inflammatory response
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050853 IDA B cell receptor signaling pathway
GO:0050855 IMP regulation of B cell receptor signaling pathway
GO:0050861 IGI positive regulation of B cell receptor signaling pathway
GO:0051219 IEA phosphoprotein binding
GO:0051272 IEA positive regulation of cellular component movement
GO:0051279 IGI regulation of release of sequestered calcium ion into cytosol
GO:0060252 IEA positive regulation of glial cell proliferation
GO:0060369 IEA positive regulation of Fc receptor mediated stimulatory signaling pathway
GO:0070062 IEA extracellular vesicular exosome
GO:0070304 IEA positive regulation of stress-activated protein kinase signaling cascade
GO:0070372 IMP regulation of ERK1 and ERK2 cascade
GO:0070373 IMP negative regulation of ERK1 and ERK2 cascade
GO:0070447 IEA positive regulation of oligodendrocyte progenitor proliferation
GO:0070667 IMP negative regulation of mast cell proliferation
GO:0070668 IEA positive regulation of mast cell proliferation
GO:0071300 IEA cellular response to retinoic acid
GO:0090025 IEA regulation of monocyte chemotaxis
GO:0090330 IMP regulation of platelet aggregation
GO:0097028 IMP dendritic cell differentiation
GO:1902532 IMP negative regulation of intracellular signal transduction
GO:2000670 IMP positive regulation of dendritic cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031715 lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog protein_coding Danio_rerio
ENSG00000254087 LYN LYN proto-oncogene, Src family tyrosine kinase protein_coding Homo_sapiens

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