Warning (512) : _cake_core_ cache was unable to write 'cake_dev_eng' to File cache [CORE/Cake/Cache/Cache.php , line 323 ]Code Context ),
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$success = false Cache::write() - CORE/Cake/Cache/Cache.php, line 323
I18n::translate() - CORE/Cake/I18n/I18n.php, line 237
__d - CORE/Cake/basics.php, line 617
Cache::write() - CORE/Cake/Cache/Cache.php, line 321
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108 Warning (512) : _cake_model_ cache was unable to write 'default_citloci_list' to File cache [CORE/Cake/Cache/Cache.php , line 323 ]Code Context ),
E_USER_WARNING
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$success = false Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
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E_USER_WARNING
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(int) 5 => 'external_accessions',
(int) 6 => 'genes',
(int) 7 => 'go_annotations',
(int) 8 => 'homologues',
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$success = false Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 236
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108 Warning (512) : _cake_model_ cache was unable to write 'default_citloci_genes' to File cache [CORE/Cake/Cache/Cache.php , line 323 ]Code Context ),
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$config = '_cake_model_'
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'lock' => true,
'isWindows' => false,
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'probability' => (int) 100,
'groups' => array()
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DataSource::_cacheDescription() - CORE/Cake/Model/Datasource/DataSource.php, line 310
DataSource::describe() - CORE/Cake/Model/Datasource/DataSource.php, line 135
Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 332
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
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Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 372
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108
Institute of Cardiovascular Regeneration Webtool Repository
C-It-Loci: A knowledge database for tissue-enriched loci.
Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main
Expression Patterns
Heat Map
Numeric Values
Transcript ';
Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis ENSMUST00000041377 ENSMUST00000103010 ENSMUST00000137943
Transcript ID
Adipose
Adrenal
Bladder
Brain
Breast
Colon
Heart
Kidney
Liver
Lung
Muscle
Ovary
Placenta
Testis
ENSMUST00000041377
3.595±0.36
N/A
3.102±0.77
0.925±0.67
4.964±2.77
3.558±0.00
1.647±0.55
1.819±0.48
4.544±2.89
7.989±0.58
0.880±0.27
3.676±1.28
3.837±1.69
0.244±0.01
ENSMUST00000103010
4.868±0.65
5.322±0.82
1.805±0.12
0.546±0.27
6.977±2.37
4.896±0.54
2.107±0.29
3.417±0.67
3.312±1.15
13.060±2.19
0.434±0.24
3.266±1.32
1.893±0.47
0.170±0.10
ENSMUST00000137943
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
4.984±0.19
N/A
N/A
Conserved Regions
Region ID Sub-Region Region Type Position
CIL_00009D
CIL_00009D_0002
CGP
4:3574875-3813122
CIL_0001U6
CIL_0001U6_0002
CGP
4:3678115-3835665
Gene Ontology
GO ID Evidence Type GO Description
GO:0001782
IMP
B cell homeostasis
GO:0001817
IMP
regulation of cytokine production
GO:0001933
IMP
negative regulation of protein phosphorylation
GO:0002431
IMP
Fc receptor mediated stimulatory signaling pathway
GO:0002513
IMP
tolerance induction to self antigen
GO:0002553
IEA
histamine secretion by mast cell
GO:0002576
IMP
platelet degranulation
GO:0002762
IMP
negative regulation of myeloid leukocyte differentiation
GO:0002768
IMP
immune response-regulating cell surface receptor signaling pathway
GO:0002774
IMP
Fc receptor mediated inhibitory signaling pathway
GO:0002902
IMP
regulation of B cell apoptotic process
GO:0004672
IDA
protein kinase activity
GO:0004713
IDA
protein tyrosine kinase activity
GO:0004715
IEA
non-membrane spanning protein tyrosine kinase activity
GO:0005102
IEA
receptor binding
GO:0005128
TAS
erythropoietin receptor binding
GO:0005161
IEA
platelet-derived growth factor receptor binding
GO:0005178
IEA
integrin binding
GO:0005515
IPI
protein binding
GO:0005524
IEA
ATP binding
GO:0005634
IDA
nucleus
GO:0005737
IDA
cytoplasm
GO:0005758
IEA
mitochondrial intermembrane space
GO:0005794
IEA
Golgi apparatus
GO:0005829
TAS
cytosol
GO:0005886
IDA
plasma membrane
GO:0006974
IEA
cellular response to DNA damage stimulus
GO:0006991
IEA
response to sterol depletion
GO:0007165
TAS
signal transduction
GO:0007169
IEA
transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284
IMP
positive regulation of cell proliferation
GO:0008285
IMP
negative regulation of cell proliferation
GO:0009636
IEA
response to toxic substance
GO:0009725
IDA
response to hormone
GO:0009743
IEA
response to carbohydrate
GO:0010976
IEA
positive regulation of neuron projection development
GO:0014003
IEA
oligodendrocyte development
GO:0014069
IEA
postsynaptic density
GO:0014070
IEA
response to organic cyclic compound
GO:0016020
IEA
membrane
GO:0017124
IPI
SH3 domain binding
GO:0018108
IDA
peptidyl-tyrosine phosphorylation
GO:0019899
IEA
enzyme binding
GO:0030061
IEA
mitochondrial crista
GO:0030097
IMP
hemopoiesis
GO:0030218
IMP
erythrocyte differentiation
GO:0030335
IMP
positive regulation of cell migration
GO:0030889
IMP
negative regulation of B cell proliferation
GO:0031175
IMP
neuron projection development
GO:0031625
IEA
ubiquitin protein ligase binding
GO:0031663
IMP
lipopolysaccharide-mediated signaling pathway
GO:0031668
IEA
cellular response to extracellular stimulus
GO:0031966
IEA
mitochondrial membrane
GO:0032403
IPI
protein complex binding
GO:0032868
IEA
response to insulin
GO:0033003
IMP
regulation of mast cell activation
GO:0033628
IEA
regulation of cell adhesion mediated by integrin
GO:0034136
IMP
negative regulation of toll-like receptor 2 signaling pathway
GO:0034144
IMP
negative regulation of toll-like receptor 4 signaling pathway
GO:0034605
IEA
cellular response to heat
GO:0034666
IEA
integrin alpha2-beta1 complex
GO:0035556
IDA
intracellular signal transduction
GO:0042327
IEA
positive regulation of phosphorylation
GO:0042493
IEA
response to drug
GO:0042531
IMP
positive regulation of tyrosine phosphorylation of STAT protein
GO:0042541
TAS
hemoglobin biosynthetic process
GO:0042629
IEA
mast cell granule
GO:0043200
IEA
response to amino acid
GO:0043208
IEA
glycosphingolipid binding
GO:0043304
IMP
regulation of mast cell degranulation
GO:0043407
IMP
negative regulation of MAP kinase activity
GO:0043434
IEA
response to peptide hormone
GO:0043552
IMP
positive regulation of phosphatidylinositol 3-kinase activity
GO:0044325
IEA
ion channel binding
GO:0045087
IEA
innate immune response
GO:0045121
IEA
membrane raft
GO:0045646
IMP
regulation of erythrocyte differentiation
GO:0046777
IDA
protein autophosphorylation
GO:0048471
IEA
perinuclear region of cytoplasm
GO:0048678
IEA
response to axon injury
GO:0050663
IEA
cytokine secretion
GO:0050707
IMP
regulation of cytokine secretion
GO:0050727
IMP
regulation of inflammatory response
GO:0050731
IDA
positive regulation of peptidyl-tyrosine phosphorylation
GO:0050853
IDA
B cell receptor signaling pathway
GO:0050855
IMP
regulation of B cell receptor signaling pathway
GO:0050861
IGI
positive regulation of B cell receptor signaling pathway
GO:0051219
IEA
phosphoprotein binding
GO:0051272
IEA
positive regulation of cellular component movement
GO:0051279
IGI
regulation of release of sequestered calcium ion into cytosol
GO:0060252
IEA
positive regulation of glial cell proliferation
GO:0060369
IEA
positive regulation of Fc receptor mediated stimulatory signaling pathway
GO:0070062
IEA
extracellular vesicular exosome
GO:0070304
IEA
positive regulation of stress-activated protein kinase signaling cascade
GO:0070372
IMP
regulation of ERK1 and ERK2 cascade
GO:0070373
IMP
negative regulation of ERK1 and ERK2 cascade
GO:0070447
IEA
positive regulation of oligodendrocyte progenitor proliferation
GO:0070667
IMP
negative regulation of mast cell proliferation
GO:0070668
IEA
positive regulation of mast cell proliferation
GO:0071300
IEA
cellular response to retinoic acid
GO:0090025
IEA
regulation of monocyte chemotaxis
GO:0090330
IMP
regulation of platelet aggregation
GO:0097028
IMP
dendritic cell differentiation
GO:1902532
IMP
negative regulation of intracellular signal transduction
GO:2000670
IMP
positive regulation of dendritic cell apoptotic process
Homologs
ENSEMBL Accession
Gene Name
Description
Biotype
Species
ENSDARG00000031715
lyn
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
protein_coding
Danio_rerio
ENSG00000254087
LYN
LYN proto-oncogene, Src family tyrosine kinase
protein_coding
Homo_sapiens
Loading
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'CakeSession' => '/var/www/c-it-loci/lib/Cake/Model/Datasource/CakeSession.php',
'View' => '/var/www/c-it-loci/lib/Cake/View/View.php',
'HelperCollection' => '/var/www/c-it-loci/lib/Cake/View/HelperCollection.php',
'ViewBlock' => '/var/www/c-it-loci/lib/Cake/View/ViewBlock.php',
'HtmlHelper' => '/var/www/c-it-loci/lib/Cake/View/Helper/HtmlHelper.php',
'AppHelper' => '/var/www/c-it-loci/app/View/Helper/AppHelper.php',
'Helper' => '/var/www/c-it-loci/lib/Cake/View/Helper.php',
'FormHelper' => '/var/www/c-it-loci/lib/Cake/View/Helper/FormHelper.php',
'SessionHelper' => '/var/www/c-it-loci/lib/Cake/View/Helper/SessionHelper.php'
)
$config = '_cake_core_'
$settings = array(
'prefix' => '*****',
'engine' => 'File',
'path' => '/var/www/c-it-loci/app/tmp/cache/persistent/',
'serialize' => true,
'duration' => (int) 10,
'lock' => true,
'isWindows' => false,
'mask' => (int) 436,
'probability' => (int) 100,
'groups' => array()
)
$success = false Cache::write() - CORE/Cake/Cache/Cache.php, line 323
App::shutdown() - CORE/Cake/Core/App.php, line 899
[main] - [internal], line ?? Warning (512) : _cake_core_ cache was unable to write 'method_cache' to File cache [CORE/Cake/Cache/Cache.php , line 323 ]Code Context ),
E_USER_WARNING
); $key = 'method_cache'
$value = array(
(int) 0 => false,
'name' => array(
'45b989c52610ac6d773f6b83d6108190' => '`citloci`',
'4d0d73f550e4b0573d9cf666d63a0244' => '`genes`',
'003d5968b53baeeb0cb27d56c4d447af' => '`Gene`.`id`',
'f32f1dc049466870a2299961f0604112' => '`Gene`.`gene_version`',
'433a39b330b04a021541e6fa89d80ffd' => '`Gene`.`tax_id`',
'56705ff3488da428f13156180dbc9fbc' => '`Gene`.`assembly`',
'b7d572bb36c8f0f2ecfe36921c14fbf3' => '`Gene`.`chromosome`',
'edf6b12f8a40424f91fa0a40f0eab275' => '`Gene`.`strand`',
'71d92ec0ad29837870abd0de3ae8addc' => '`Gene`.`start`',
'62e43d606bf4cdae2d6694c62e19e7fa' => '`Gene`.`end`',
'7043386674301bd31c5e629dfdadabd4' => '`Gene`.`gene_name`',
'f1454297621ddcf07c418e47f67d3857' => '`Gene`.`gene_source`',
'27d53785bfcd771f1901030b4bb87d02' => '`Gene`.`gene_biotype`',
'b93574bf8a03f2d6f6486e920115e0d1' => '`Gene`.`annotation_version`',
'1c4a3f5d90070e8ea1c62ca077df603e' => '`Gene`.`gene_description`',
'8ca7a0c53312b8ae3cfa40a9d814adac' => '`Gene`'
),
'fields' => array(
'0ea8c82680a14e2566476c4ab527af47' => array(
(int) 0 => '`Gene`.`id`',
(int) 1 => '`Gene`.`gene_version`',
(int) 2 => '`Gene`.`tax_id`',
(int) 3 => '`Gene`.`assembly`',
(int) 4 => '`Gene`.`chromosome`',
(int) 5 => '`Gene`.`strand`',
(int) 6 => '`Gene`.`start`',
(int) 7 => '`Gene`.`end`',
(int) 8 => '`Gene`.`gene_name`',
(int) 9 => '`Gene`.`gene_source`',
(int) 10 => '`Gene`.`gene_biotype`',
(int) 11 => '`Gene`.`annotation_version`',
(int) 12 => '`Gene`.`gene_description`'
)
)
)
$config = '_cake_core_'
$settings = array(
'prefix' => '*****',
'engine' => 'File',
'path' => '/var/www/c-it-loci/app/tmp/cache/persistent/',
'serialize' => true,
'duration' => (int) 10,
'lock' => true,
'isWindows' => false,
'mask' => (int) 436,
'probability' => (int) 100,
'groups' => array()
)
$success = false Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DboSource::__destruct() - CORE/Cake/Model/Datasource/DboSource.php, line 3539
[main] - [internal], line ??