C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: FMS-like tyrosine kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000042817 Flt3 10090 - 5:147330741-147400489 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000049324 Flt3-001 147330741-147400489 protein_coding
  ENSMUST00000110549 Flt3-002 147362557-147400489 protein_coding
  ENSMUST00000176456 Flt3-003 147330741-147400489 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000049324ENSMUST00000110549ENSMUST00000176456
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000049324 0.521±0.35 0.062±0.02 0.675±0.23 0.303±0.26 1.861±0.83 0.273±0.06 0.045±0.02 0.246±0.12 0.436±0.38 1.010±0.34 0.272±0.00 0.260±0.14 5.424±7.52 0.379±0.16
ENSMUST00000110549 N/A 0.111±0.03 N/A 0.053±0.01 0.230±0.08 0.052±0.01 0.008±0.00 0.020±0.00 N/A 0.089±0.00 N/A 0.114±0.06 N/A N/A
ENSMUST00000176456 0.035±0.00 0.035±0.01 0.069±0.00 0.147±0.06 0.319±0.16 0.108±0.02 0.021±0.01 0.033±0.00 0.143±0.12 0.152±0.02 0.076±0.05 0.194±0.09 0.753±1.14 0.086±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008CO CIL_0008CO_0002 VISTA 5:146855041-147456530
CIL_00082E CIL_00082E_0002 VISTA 5:146922660-147524221
CIL_0007MT CIL_0007MT_0002 UCNEbase 5:146994099-147547626
CIL_0000G8 CIL_0000G8_0003 CGP 5:147314984-147400489
CIL_0000G0 CIL_0000G0_0003 CGP 5:147330741-147548502

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001934 IGI positive regulation of protein phosphorylation
GO:0002318 IMP myeloid progenitor cell differentiation
GO:0002320 IGI lymphoid progenitor cell differentiation
GO:0002328 IMP pro-B cell differentiation
GO:0002572 IMP pro-T cell differentiation
GO:0004713 IDA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005829 IEA cytosol
GO:0005886 IEA plasma membrane
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008285 IMP negative regulation of cell proliferation
GO:0009897 IDA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0010243 IEA response to organonitrogen compound
GO:0016021 IEA integral component of membrane
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030097 ISO hemopoiesis
GO:0030098 IDA lymphocyte differentiation
GO:0031100 IEA organ regeneration
GO:0032403 IEA protein complex binding
GO:0035259 IEA glucocorticoid receptor binding
GO:0043234 IEA protein complex
GO:0043548 IDA phosphatidylinositol 3-kinase binding
GO:0045578 IDA negative regulation of B cell differentiation
GO:0046777 IDA protein autophosphorylation
GO:0071385 IEA cellular response to glucocorticoid stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058503 flt3 fms-related tyrosine kinase 3 protein_coding Danio_rerio
ENSG00000122025 FLT3 fms-related tyrosine kinase 3 protein_coding Homo_sapiens

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