C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: atypical chemokine receptor 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000044337 Ackr3 10090 + 1:90203980-90216751 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000065587 Ackr3-001 90203980-90216751 protein_coding
  ENSMUST00000159654 Ackr3-002 90204006-90213833 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000065587
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000065587 84.033±34.12 162.011±11.25 28.421±0.00 14.001±11.99 81.603±20.14 29.701±5.94 84.359±20.51 67.642±18.36 1.945±0.91 39.028±5.30 2.659±1.68 47.409±23.78 10.237±6.04 4.173±2.17

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008K4 CIL_0008K4_0002 VISTA 1:89625517-90226000
CIL_0007XN CIL_0007XN_0002 VISTA 1:89706775-90307806
CIL_0008Q8 CIL_0008Q8_0002 VISTA 1:89946249-90547693
CIL_0007QN CIL_0007QN_0002 VISTA 1:89988936-90590388
CIL_0002W2 CIL_0002W2_0002 CGP 1:90042132-90216751
CIL_0000XT CIL_0000XT_0002 CGP 1:90203980-90613341

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001570 IEA vasculogenesis
GO:0005044 ISS scavenger receptor activity
GO:0005515 IEA protein binding
GO:0005768 ISS endosome
GO:0005886 ISS plasma membrane
GO:0005905 ISS coated pit
GO:0006935 IEA chemotaxis
GO:0007155 IEA cell adhesion
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0009986 ISS cell surface
GO:0015026 IEA coreceptor activity
GO:0016021 IEA integral component of membrane
GO:0016494 IEA C-X-C chemokine receptor activity
GO:0019958 ISS C-X-C chemokine binding
GO:0031623 ISS receptor internalization
GO:0070098 IEA chemokine-mediated signaling pathway
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:1902230 IEA negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058179 ackr3b atypical chemokine receptor 3b protein_coding Danio_rerio
ENSDARG00000062478 ACKR3 (2 of 2) atypical chemokine receptor 3 protein_coding Danio_rerio
ENSG00000144476 ACKR3 atypical chemokine receptor 3 protein_coding Homo_sapiens

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