C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: atypical chemokine receptor 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000144476 ACKR3 9606 + 2:236567787-236582358 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000272928 ACKR3-001 236569641-236582358 protein_coding
  ENST00000447924 ACKR3-002 236567787-236581097 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000272928ENST00000447924
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000272928 10.976±0.00 4.465±0.00 0.227±0.00 0.423±0.32 5.226±2.39 4.895±3.72 1.496±0.09 0.879±0.00 2.280±0.65 2.848±1.27 2.584±1.70 1.399±0.80 13.917±1.47 2.070±0.00
ENST00000447924 26.166±0.00 15.772±0.00 0.132±0.00 2.755±1.47 13.134±11.88 10.232±6.96 2.703±2.19 3.640±0.00 5.547±0.00 5.549±4.70 3.988±0.00 4.343±1.58 17.780±4.86 7.505±0.05

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008Q8 CIL_0008Q8_0001 VISTA 2:236320043-236922418
CIL_0002W2 CIL_0002W2_0001 CGP 2:236324147-236582358
CIL_0007QN CIL_0007QN_0001 VISTA 2:236387535-236989164
CIL_0000XT CIL_0000XT_0001 CGP 2:236567787-237100466

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001570 IEA vasculogenesis
GO:0004930 IEA G-protein coupled receptor activity
GO:0005044 IMP scavenger receptor activity
GO:0005515 IPI protein binding
GO:0005768 IDA endosome
GO:0005886 IDA plasma membrane
GO:0005905 IDA coated pit
GO:0006935 IEA chemotaxis
GO:0007155 IEA cell adhesion
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0009986 IDA cell surface
GO:0015026 IEA coreceptor activity
GO:0016021 IEA integral component of membrane
GO:0016032 IEA viral process
GO:0016494 IMP C-X-C chemokine receptor activity
GO:0019958 IMP C-X-C chemokine binding
GO:0031623 IMP receptor internalization
GO:0070098 IMP chemokine-mediated signaling pathway
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:1902230 IMP negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058179 ackr3b atypical chemokine receptor 3b protein_coding Danio_rerio
ENSDARG00000062478 ACKR3 (2 of 2) atypical chemokine receptor 3 protein_coding Danio_rerio
ENSMUSG00000044337 Ackr3 atypical chemokine receptor 3 protein_coding Mus_musculus

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