C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: O-6-methylguanine-DNA methyltransferase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000054612 Mgmt 10090 + 7:136894611-137128187 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000081510 Mgmt-201 136894611-137128187 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000081510
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000081510 14.312±4.28 5.901±1.17 8.426±0.45 1.085±0.55 9.031±2.64 4.474±0.76 7.544±1.02 8.054±1.78 13.052±8.10 3.499±0.72 4.571±1.26 12.717±3.93 2.536±2.14 2.302±0.49

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001LH CIL_0001LH_0002 CGP 7:135689788-137128187
CIL_0007OP CIL_0007OP_0002 UCNEbase 7:135757037-137452523
CIL_0007TK CIL_0007TK_0002 VISTA 7:136437154-137039340
CIL_00081R CIL_00081R_0002 VISTA 7:136702009-137303274
CIL_00097C CIL_00097C_0002 VISTA 7:136705038-137306321
CIL_0009BD CIL_0009BD_0002 VISTA 7:136739207-137341141
CIL_0008TP CIL_0008TP_0002 VISTA 7:136791736-137393087
CIL_0001LI CIL_0001LI_0002 CGP 7:136894611-137314445

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003677 IEA DNA binding
GO:0003908 IEA methylated-DNA-[protein]-cysteine S-methyltransferase activity
GO:0005509 IEA calcium ion binding
GO:0005634 IEA nucleus
GO:0006281 IMP DNA repair
GO:0006307 IDA DNA dealkylation involved in DNA repair
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0008168 IDA methyltransferase activity
GO:0009636 IEA response to toxic substance
GO:0014070 IEA response to organic cyclic compound
GO:0016020 IEA membrane
GO:0032259 IEA methylation
GO:0034599 IEA cellular response to oxidative stress
GO:0042493 IEA response to drug
GO:0043281 IMP regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045471 IEA response to ethanol
GO:0045739 IEA positive regulation of DNA repair
GO:0051593 IEA response to folic acid
GO:0060548 IEA negative regulation of cell death
GO:0060644 IEA mammary gland epithelial cell differentiation
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071479 IEA cellular response to ionizing radiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000043275 mgmt O-6-methylguanine-DNA methyltransferase protein_coding Danio_rerio
ENSG00000170430 MGMT O-6-methylguanine-DNA methyltransferase protein_coding Homo_sapiens

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