C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutamate receptor, ionotropic, kainate 2 (beta 2)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000056073 Grik2 10090 - 10:49099460-49788766 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000079751 Grik2-201 49105018-49783259 protein_coding
  ENSMUST00000105483 Grik2-002 49495438-49788754 protein_coding
  ENSMUST00000105484 Grik2-202 49099843-49783259 protein_coding
  ENSMUST00000105485 Grik2-004 49100989-49783409 protein_coding
  ENSMUST00000105486 Grik2-005 49100727-49783259 protein_coding
  ENSMUST00000105487 Grik2-001 49099460-49788766 protein_coding
  ENSMUST00000129279 Grik2-006 49101128-49103931 retained_intron
  ENSMUST00000147808 Grik2-003 49099843-49243036 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000079751ENSMUST00000105483ENSMUST00000105484ENSMUST00000105485ENSMUST00000105486ENSMUST00000105487ENSMUST00000129279ENSMUST00000147808
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000079751 0.770±0.03 0.556±0.23 N/A 6.539±0.00 0.076±0.04 0.083±0.00 0.111±0.03 0.061±0.03 0.018±0.01 0.203±0.07 N/A 0.259±0.16 0.013±0.00 1.157±0.78
ENSMUST00000105483 0.206±0.00 0.309±0.27 N/A N/A 0.081±0.07 0.092±0.01 0.118±0.02 0.067±0.02 N/A 0.089±0.04 0.010±0.00 0.164±0.10 N/A N/A
ENSMUST00000105484 N/A N/A 0.040±0.00 N/A N/A N/A N/A N/A 0.024±0.02 N/A 0.028±0.02 0.045±0.00 N/A N/A
ENSMUST00000105485 N/A N/A N/A 1.750±0.00 0.016±0.00 0.152±0.00 N/A 0.023±0.00 N/A N/A 0.040±0.00 0.044±0.00 0.026±0.01 0.071±0.00
ENSMUST00000105486 N/A N/A 0.090±0.00 N/A N/A N/A N/A N/A 0.007±0.00 0.063±0.00 N/A N/A N/A 0.237±0.13
ENSMUST00000105487 0.015±0.00 0.240±0.15 0.050±0.00 8.180±0.31 0.084±0.01 0.160±0.00 0.052±0.02 0.046±0.00 0.030±0.02 0.117±0.08 0.018±0.00 0.094±0.04 0.007±0.00 N/A
ENSMUST00000129279 N/A N/A N/A N/A N/A N/A 0.304±0.00 N/A N/A N/A N/A 1.440±0.00 N/A N/A
ENSMUST00000147808 N/A 0.319±0.08 N/A 5.376±2.67 0.032±0.00 0.040±0.00 N/A 0.010±0.00 0.006±0.00 N/A 0.012±0.00 0.074±0.02 0.011±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001662 IMP behavioral fear response
GO:0004970 IMP ionotropic glutamate receptor activity
GO:0005234 IBA extracellular-glutamate-gated ion channel activity
GO:0005515 IPI protein binding
GO:0005887 IEA integral component of plasma membrane
GO:0006874 IMP cellular calcium ion homeostasis
GO:0006886 IDA intracellular protein transport
GO:0007165 IEA signal transduction
GO:0007268 IGI synaptic transmission
GO:0008066 IEA glutamate receptor activity
GO:0008328 IC ionotropic glutamate receptor complex
GO:0014069 IDA postsynaptic density
GO:0015277 IMP kainate selective glutamate receptor activity
GO:0016020 IDA membrane
GO:0019228 IMP neuronal action potential
GO:0030054 IEA cell junction
GO:0030165 IEA PDZ domain binding
GO:0030424 IEA axon
GO:0030425 IBA dendrite
GO:0031624 IEA ubiquitin conjugating enzyme binding
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032839 IEA dendrite cytoplasm
GO:0032983 IPI kainate selective glutamate receptor complex
GO:0034220 IEA ion transmembrane transport
GO:0035235 IEA ionotropic glutamate receptor signaling pathway
GO:0035249 IMP synaptic transmission, glutamatergic
GO:0042391 IMP regulation of membrane potential
GO:0042734 IDA presynaptic membrane
GO:0042802 IEA identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0043025 IDA neuronal cell body
GO:0043113 IEA receptor clustering
GO:0043195 IEA terminal bouton
GO:0043204 IEA perikaryon
GO:0043524 IGI negative regulation of neuron apoptotic process
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0045202 TAS synapse
GO:0045211 IDA postsynaptic membrane
GO:0046328 IEA regulation of JNK cascade
GO:0048169 IMP regulation of long-term neuronal synaptic plasticity
GO:0048172 IMP regulation of short-term neuronal synaptic plasticity
GO:0050804 IEA regulation of synaptic transmission
GO:0050806 IEA positive regulation of synaptic transmission
GO:0051402 IEA neuron apoptotic process
GO:0051967 IGI negative regulation of synaptic transmission, glutamatergic
GO:0060079 IMP regulation of excitatory postsynaptic membrane potential
GO:0060080 IGI regulation of inhibitory postsynaptic membrane potential

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074515 GRIK2 (1 of 2) glutamate receptor, ionotropic, kainate 2 protein_coding Danio_rerio
ENSG00000164418 GRIK2 glutamate receptor, ionotropic, kainate 2 protein_coding Homo_sapiens

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