C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: thyroid hormone receptor alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000058756 Thra 10090 + 11:98740638-98769006 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000064187 Thra-001 98741811-98769006 protein_coding
  ENSMUST00000103139 Thra-003 98741873-98765111 protein_coding
  ENSMUST00000124072 Thra-004 98753586-98768403 protein_coding
  ENSMUST00000124130 Thra-008 98740904-98753442 processed_transcript
  ENSMUST00000142944 Thra-005 98740638-98753379 processed_transcript
  ENSMUST00000150693 Thra-006 98744233-98753777 processed_transcript
  ENSMUST00000152195 Thra-002 98741811-98757695 processed_transcript
  ENSMUST00000153043 Thra-007 98742158-98756995 protein_coding
  ENSMUST00000153468 Thra-009 98740801-98753638 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000064187ENSMUST00000103139ENSMUST00000124072ENSMUST00000152195ENSMUST00000153043
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000064187 43.671±1.88 53.175±9.33 31.403±2.25 184.638±27.30 47.251±4.62 36.750±2.72 30.815±2.43 38.152±3.80 6.875±1.34 63.587±9.25 18.154±3.25 48.048±18.71 5.501±3.71 4.633±0.60
ENSMUST00000103139 N/A N/A N/A N/A N/A 14.216±0.00 N/A N/A 3.072±1.10 N/A 10.069±1.48 17.767±0.85 N/A N/A
ENSMUST00000124072 N/A N/A N/A 103.134±32.33 N/A N/A N/A N/A 6.240±0.72 N/A N/A 26.914±0.00 4.003±0.00 N/A
ENSMUST00000152195 N/A 68.154±2.98 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000153043 N/A N/A N/A 342.474±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.860±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00098Y CIL_00098Y_0002 VISTA 11:98447152-99051430
CIL_0002KL CIL_0002KL_0002 CGP 11:98704591-98769006
CIL_0002L8 CIL_0002L8_0002 CGP 11:98740638-98775333

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001502 IMP cartilage condensation
GO:0001503 IMP ossification
GO:0002153 IDA steroid receptor RNA activator RNA binding
GO:0002155 IMP regulation of thyroid hormone mediated signaling pathway
GO:0003707 IEA steroid hormone receptor activity
GO:0003727 IDA single-stranded RNA binding
GO:0004879 IDA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004887 TAS:ISS thyroid hormone receptor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007611 IMP learning or memory
GO:0008016 IMP regulation of heart contraction
GO:0008050 IMP female courtship behavior
GO:0008134 IEA transcription factor binding
GO:0008270 IEA zinc ion binding
GO:0009409 IMP response to cold
GO:0009755 IEA hormone-mediated signaling pathway
GO:0009887 IMP organ morphogenesis
GO:0010831 IDA positive regulation of myotube differentiation
GO:0017025 IEA TBP-class protein binding
GO:0017055 IEA negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0019904 IEA protein domain specific binding
GO:0030218 IMP erythrocyte differentiation
GO:0030522 IDA:IEA intracellular receptor signaling pathway
GO:0030878 IGI thyroid gland development
GO:0031490 IDA chromatin DNA binding
GO:0032403 IDA protein complex binding
GO:0033032 IMP regulation of myeloid cell apoptotic process
GO:0042994 IDA cytoplasmic sequestering of transcription factor
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045925 IMP positive regulation of female receptivity
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0050994 IMP regulation of lipid catabolic process
GO:0060509 IGI Type I pneumocyte differentiation
GO:0070324 ISO:ISS thyroid hormone binding
GO:2000143 IEA negative regulation of DNA-templated transcription, initiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000000151 thraa thyroid hormone receptor alpha a protein_coding Danio_rerio
ENSDARG00000052654 thrab thyroid hormone receptor alpha b protein_coding Danio_rerio
ENSG00000126351 THRA thyroid hormone receptor, alpha protein_coding Homo_sapiens

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