C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fragile histidine triad gene
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000060579 Fhit 10090 - 14:9550092-11162035 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000160340 Fhit-002 9550100-11162035 protein_coding
  ENSMUST00000160956 Fhit-004 9870107-11162035 protein_coding
  ENSMUST00000161179 Fhit-005 9763680-11125179 retained_intron
  ENSMUST00000161302 Fhit-001 9550092-10453458 protein_coding
  ENSMUST00000161895 Fhit-006 9573488-11125591 protein_coding
  ENSMUST00000162278 Fhit-003 9550100-11162032 protein_coding
  ENSMUST00000162817 Fhit-007 9763787-11125562 protein_coding
  ENSMUST00000179394 Fhit-201 9550393-10421597 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000160340ENSMUST00000160956ENSMUST00000161179ENSMUST00000161302ENSMUST00000161895ENSMUST00000162278ENSMUST00000162817ENSMUST00000179394
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000160340 N/A 0.369±0.03 N/A N/A N/A N/A 0.283±0.19 N/A N/A N/A 0.251±0.00 N/A N/A 0.290±0.12
ENSMUST00000160956 N/A 2.099±0.42 N/A N/A N/A N/A 1.252±0.00 5.350±0.00 N/A N/A 0.114±0.00 1.925±0.00 N/A N/A
ENSMUST00000161179 N/A N/A N/A N/A 0.795±0.00 N/A N/A N/A 0.502±0.00 N/A N/A N/A N/A N/A
ENSMUST00000161302 2.253±0.98 0.883±0.28 3.458±0.88 1.137±0.37 1.058±0.42 1.709±1.29 0.620±0.36 9.761±0.94 2.444±1.64 0.801±0.26 0.249±0.05 2.820±1.31 1.675±1.20 0.752±0.28
ENSMUST00000161895 N/A 0.840±0.58 N/A N/A N/A N/A 0.210±0.00 N/A N/A N/A N/A 2.122±0.47 N/A 0.361±0.00
ENSMUST00000162278 N/A N/A N/A 0.218±0.00 0.381±0.00 N/A 0.566±0.00 N/A N/A 0.609±0.08 N/A 0.884±0.00 0.218±0.00 0.185±0.03
ENSMUST00000162817 N/A 0.501±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.136±0.00 N/A N/A N/A
ENSMUST00000179394 2.681±0.84 2.030±0.90 2.959±0.00 1.406±0.49 2.091±0.78 1.751±0.86 0.888±0.45 5.154±0.86 1.883±1.02 0.862±0.00 0.244±0.15 3.463±2.12 1.159±0.00 2.475±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00034H CIL_00034H_0002 CGP 14:8431192-11162035

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0003824 TAS catalytic activity
GO:0005515 IEA protein binding
GO:0005737 IDA cytoplasm
GO:0005829 ISS cytosol
GO:0006163 ISS purine nucleotide metabolic process
GO:0006260 IDA DNA replication
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0009117 TAS nucleotide metabolic process
GO:0016787 IDA hydrolase activity
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032435 ISS negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042802 IEA identical protein binding
GO:0047710 IDA bis(5'-adenosyl)-triphosphatase activity
GO:0070062 IEA extracellular vesicular exosome
GO:0072332 ISS intrinsic apoptotic signaling pathway by p53 class mediator

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000068850 fhit fragile histidine triad gene protein_coding Danio_rerio
ENSDARG00000078195 fhit fragile histidine triad gene protein_coding Danio_rerio
ENSG00000189283 FHIT fragile histidine triad protein_coding Homo_sapiens

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