C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: activin receptor IIB
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000061393 Acvr2b 10090 + 9:119402444-119433501 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000035093 Acvr2b-201 119402444-119433501 protein_coding
  ENSMUST00000165044 Acvr2b-202 119402501-119433501 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000035093ENSMUST00000165044
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000035093 0.874±0.00 0.519±0.10 2.483±0.00 0.461±0.33 1.081±0.41 0.386±0.07 0.855±0.42 0.272±0.16 0.786±0.00 0.690±0.00 1.846±0.71 N/A 0.240±0.00
ENSMUST00000165044 0.573±0.21 0.817±0.00 3.799±1.72 0.828±0.52 0.818±0.29 0.601±0.14 0.415±0.03 0.541±0.19 0.966±0.31 1.650±0.00 1.824±1.05 14.681±0.00 0.506±0.12

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008BE CIL_0008BE_0002 VISTA 9:119196374-119798584
CIL_0005W6 CIL_0005W6_0002 CGP 9:119357381-119433501
CIL_0005W0 CIL_0005W0_0002 CGP 9:119402444-119465517

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001501 IGI skeletal system development
GO:0001702 IGI gastrulation with mouth forming second
GO:0001822 IGI kidney development
GO:0001946 IMP lymphangiogenesis
GO:0001974 IMP blood vessel remodeling
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0004712 IDA protein serine/threonine/tyrosine kinase activity
GO:0005024 IEA transforming growth factor beta-activated receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005886 TAS plasma membrane
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0007165 IEA signal transduction
GO:0007368 IGI determination of left/right symmetry
GO:0007389 IGI pattern specification process
GO:0007498 IGI mesoderm development
GO:0007507 IGI heart development
GO:0009749 IGI response to glucose
GO:0009791 IGI post-embryonic development
GO:0009952 IGI anterior/posterior pattern specification
GO:0009966 IDA regulation of signal transduction
GO:0016021 IEA integral component of membrane
GO:0019838 IPI growth factor binding
GO:0023014 IEA signal transduction by phosphorylation
GO:0030073 IGI insulin secretion
GO:0030324 IGI lung development
GO:0030501 IEA positive regulation of bone mineralization
GO:0030509 IEA BMP signaling pathway
GO:0031016 IGI pancreas development
GO:0032147 IDA activation of protein kinase activity
GO:0032927 IEA positive regulation of activin receptor signaling pathway
GO:0034711 IEA inhibin binding
GO:0035265 IGI organ growth
GO:0042475 IMP odontogenesis of dentin-containing tooth
GO:0043234 ISO protein complex
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0046872 IEA metal ion binding
GO:0048185 IPI activin binding
GO:0048617 IMP embryonic foregut morphogenesis
GO:0048705 IGI skeletal system morphogenesis
GO:0060021 IGI palate development
GO:0060836 IMP lymphatic endothelial cell differentiation
GO:0060840 IMP artery development
GO:0060841 IMP venous blood vessel development
GO:0061298 IMP retina vasculature development in camera-type eye

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041516 ACVR2B (1 of 2) activin A receptor, type IIB protein_coding Danio_rerio
ENSDARG00000044422 acvr2b activin receptor IIb protein_coding Danio_rerio
ENSG00000114739 ACVR2B activin A receptor, type IIB protein_coding Homo_sapiens

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