C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000062312 Erbb2 10090 + 11:98412470-98437716 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000058295 Erbb2-001 98412470-98437716 protein_coding
  ENSMUST00000136032 Erbb2-002 98412493-98437077 processed_transcript
  ENSMUST00000138066 Erbb2-003 98427080-98427572 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000058295ENSMUST00000136032
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000058295 3.802±2.09 1.352±0.34 10.576±0.31 1.773±0.26 4.127±0.66 32.656±4.85 1.242±0.26 12.935±1.03 0.934±0.15 7.097±1.12 0.554±0.09 7.652±2.17 1.914±0.44 0.550±0.13
ENSMUST00000136032 3.328±0.79 1.683±0.66 5.488±1.03 1.636±0.16 4.027±2.33 22.276±7.02 N/A 8.106±2.78 N/A 5.798±1.48 0.431±0.00 5.369±1.52 1.992±0.56 0.571±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008SN CIL_0008SN_0002 VISTA 11:97857859-98458466
CIL_00080Z CIL_00080Z_0002 VISTA 11:98039002-98639485
CIL_00098W CIL_00098W_0002 VISTA 11:98077499-98680383
CIL_0007WH CIL_0007WH_0002 VISTA 11:98091902-98695006
CIL_0002PO CIL_0002PO_0002 CGP 11:98388677-98437716
CIL_0002PN CIL_0002PN_0002 CGP 11:98412470-98438991

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001042 ISS RNA polymerase I core binding
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0004714 ISS transmembrane receptor protein tyrosine kinase activity
GO:0004716 IEA receptor signaling protein tyrosine kinase activity
GO:0004888 IEA transmembrane signaling receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0007165 IEA signal transduction
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007169 ISS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 IMP nervous system development
GO:0007422 IMP peripheral nervous system development
GO:0007507 IMP heart development
GO:0007528 IMP neuromuscular junction development
GO:0008022 IEA protein C-terminus binding
GO:0008045 IMP motor neuron axon guidance
GO:0010008 IEA endosome membrane
GO:0014065 IEA phosphatidylinositol 3-kinase signaling
GO:0016021 NAS integral component of membrane
GO:0016323 IEA basolateral plasma membrane
GO:0016324 IDA apical plasma membrane
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019838 IEA growth factor binding
GO:0019903 IEA protein phosphatase binding
GO:0023014 IEA signal transduction by phosphorylation
GO:0030307 ISS positive regulation of cell growth
GO:0031410 IDA cytoplasmic vesicle
GO:0032321 IMP positive regulation of Rho GTPase activity
GO:0032886 ISS regulation of microtubule-based process
GO:0033088 IMP negative regulation of immature T cell proliferation in thymus
GO:0042060 IEA wound healing
GO:0042552 IMP myelination
GO:0042802 IEA identical protein binding
GO:0043235 ISO receptor complex
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0045727 ISS positive regulation of translation
GO:0045785 IEA positive regulation of cell adhesion
GO:0045943 ISS positive regulation of transcription from RNA polymerase I promoter
GO:0045945 ISS positive regulation of transcription from RNA polymerase III promoter
GO:0046777 IEA protein autophosphorylation
GO:0046982 IEA protein heterodimerization activity
GO:0048709 IMP oligodendrocyte differentiation
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0070372 ISS regulation of ERK1 and ERK2 cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000026294 erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog protein_coding Danio_rerio
ENSG00000141736 ERBB2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 protein_coding Homo_sapiens

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