C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000141736 ERBB2 9606 + 17:39687914-39730426 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000269571 ERBB2-008 39700080-39728662 protein_coding
  ENST00000406381 ERBB2-201 39694931-39728662 protein_coding
  ENST00000445658 ERBB2-004 39699976-39728079 protein_coding
  ENST00000541774 ERBB2-202 39699560-39728662 protein_coding
  ENST00000578199 ERBB2-003 39688119-39717657 protein_coding
  ENST00000578373 ERBB2-007 39700080-39728577 nonsense_mediated_decay
  ENST00000578502 ERBB2-015 39710356-39715292 protein_coding
  ENST00000578630 ERBB2-016 39716974-39723968 retained_intron
  ENST00000578709 ERBB2-012 39703194-39708492 protein_coding
  ENST00000580074 ERBB2-018 39717429-39725203 protein_coding
  ENST00000582648 ERBB2-011 39700074-39716311 nonsense_mediated_decay
  ENST00000582788 ERBB2-006 39700074-39717655 retained_intron
  ENST00000582818 ERBB2-019 39716551-39723950 protein_coding
  ENST00000583038 ERBB2-010 39707404-39726351 retained_intron
  ENST00000583391 ERBB2-014 39709244-39710410 retained_intron
  ENST00000584014 ERBB2-002 39688101-39695181 retained_intron
  ENST00000584099 ERBB2-013 39706749-39709385 protein_coding
  ENST00000584450 ERBB2-005 39700024-39728044 protein_coding
  ENST00000584601 ERBB2-001 39687914-39728361 protein_coding
  ENST00000584684 ERBB2-017 39717343-39720297 retained_intron
  ENST00000584888 ERBB2-020 39728386-39730426 processed_transcript
  ENST00000584908 ERBB2-009 39700227-39712330 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000269571ENST00000406381ENST00000541774ENST00000578373ENST00000580074ENST00000583038ENST00000583391ENST00000584450ENST00000584601
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000269571 N/A N/A N/A N/A N/A N/A 3.548±2.54 N/A N/A 1.967±0.00 N/A 24.719±0.00 N/A N/A
ENST00000406381 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.589±0.00
ENST00000541774 N/A N/A 5.517±0.00 N/A 1.548±0.00 4.112±0.00 N/A 3.962±0.00 1.493±0.00 N/A 2.022±1.30 24.729±0.00 30.097±7.67 N/A
ENST00000578373 6.135±0.00 5.196±0.00 N/A 4.055±0.00 21.456±0.00 17.939±0.00 14.076±0.00 21.114±0.00 3.162±0.00 33.275±0.00 3.600±2.55 31.615±0.00 25.072±0.00 N/A
ENST00000580074 N/A N/A 26.973±0.00 N/A 10.131±0.00 15.291±0.00 5.826±0.00 7.780±0.00 9.025±0.00 9.729±0.00 3.931±0.00 44.626±0.00 N/A N/A
ENST00000583038 N/A N/A N/A N/A N/A 1.542±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000583391 N/A N/A N/A N/A N/A N/A 6.117±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000584450 N/A N/A N/A N/A N/A N/A 0.976±0.00 N/A N/A N/A N/A 31.095±0.00 17.768±0.00 N/A
ENST00000584601 N/A N/A N/A N/A 1.320±0.00 N/A N/A N/A 0.980±0.00 N/A N/A N/A N/A 3.078±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008SN CIL_0008SN_0001 VISTA 17:39110111-39710718
CIL_00080Z CIL_00080Z_0001 VISTA 17:39318232-39918735
CIL_00098W CIL_00098W_0001 VISTA 17:39359510-39962707
CIL_0007WH CIL_0007WH_0001 VISTA 17:39374871-39978277
CIL_0002PP CIL_0002PP_0001 CGP 17:39667981-39696797
CIL_0002PO CIL_0002PO_0001 CGP 17:39671122-39730426
CIL_0002PN CIL_0002PN_0001 CGP 17:39687914-39730787

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001042 IDA RNA polymerase I core binding
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0004672 IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004714 IEA:IDA transmembrane receptor protein tyrosine kinase activity
GO:0004716 IEA receptor signaling protein tyrosine kinase activity
GO:0004888 IDA transmembrane signaling receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006468 TAS:IEA protein phosphorylation
GO:0007165 IDA signal transduction
GO:0007166 IDA cell surface receptor signaling pathway
GO:0007167 TAS enzyme linked receptor protein signaling pathway
GO:0007169 IEA:IDA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007399 IEA nervous system development
GO:0007411 TAS axon guidance
GO:0007422 IEA peripheral nervous system development
GO:0007507 IEA heart development
GO:0007528 IEA neuromuscular junction development
GO:0008022 IPI protein C-terminus binding
GO:0008045 IEA motor neuron axon guidance
GO:0008283 TAS cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010008 IDA endosome membrane
GO:0014065 IDA phosphatidylinositol 3-kinase signaling
GO:0016020 IEA membrane
GO:0016021 NAS:IEA integral component of membrane
GO:0016323 IDA basolateral plasma membrane
GO:0016324 IEA apical plasma membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019838 IDA growth factor binding
GO:0019903 IPI protein phosphatase binding
GO:0023014 IEA signal transduction by phosphorylation
GO:0030307 IMP positive regulation of cell growth
GO:0031410 IEA cytoplasmic vesicle
GO:0032321 ISS positive regulation of Rho GTPase activity
GO:0032886 IDA regulation of microtubule-based process
GO:0033088 IEA negative regulation of immature T cell proliferation in thymus
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042060 IDA wound healing
GO:0042552 IEA myelination
GO:0042802 IPI identical protein binding
GO:0043125 TAS ErbB-3 class receptor binding
GO:0043235 IDA receptor complex
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0045087 TAS innate immune response
GO:0045727 IMP positive regulation of translation
GO:0045765 NAS regulation of angiogenesis
GO:0045785 IDA positive regulation of cell adhesion
GO:0045943 IMP positive regulation of transcription from RNA polymerase I promoter
GO:0045945 IDA positive regulation of transcription from RNA polymerase III promoter
GO:0046777 IDA protein autophosphorylation
GO:0046982 IDA protein heterodimerization activity
GO:0046983 NAS protein dimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048709 IEA oligodendrocyte differentiation
GO:0050679 IDA positive regulation of epithelial cell proliferation
GO:0070372 IMP regulation of ERK1 and ERK2 cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000026294 erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog protein_coding Danio_rerio
ENSMUSG00000062312 Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) protein_coding Mus_musculus

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