C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: epidermal growth factor receptor
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000020329 Egfr-001 ENSMUSG00000020122 10090 + 11:16752211-16918158 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000020329
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000020329 6.977±2.70 0.803±0.12 3.524±0.25 1.030±0.26 8.054±0.86 4.744±0.42 0.787±0.04 4.476±0.61 16.824±17.48 3.034±0.35 0.598±0.10 8.595±2.42 2.342±1.43 0.299±0.12

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000647 CIL_000647_0002 CGP 11:16500530-16918158

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000186 IEA activation of MAPKK activity
GO:0000902 IGI cell morphogenesis
GO:0001889 IEA liver development
GO:0001892 IMP embryonic placenta development
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0001942 IMP hair follicle development
GO:0001948 IEA glycoprotein binding
GO:0003682 ISS chromatin binding
GO:0004713 ISS protein tyrosine kinase activity
GO:0004716 IEA receptor signaling protein tyrosine kinase activity
GO:0004871 IDA signal transducer activity
GO:0004888 IEA transmembrane signaling receptor activity
GO:0005006 IDA epidermal growth factor-activated receptor activity
GO:0005102 IEA receptor binding
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005622 IDA intracellular
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0005768 ISS endosome
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0005925 IEA focal adhesion
GO:0006412 IEA translation
GO:0006970 IEA response to osmotic stress
GO:0006979 IEA response to oxidative stress
GO:0007165 IDA signal transduction
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007173 IDA epidermal growth factor receptor signaling pathway
GO:0007435 IMP salivary gland morphogenesis
GO:0007611 IEA learning or memory
GO:0007623 IEA circadian rhythm
GO:0008283 IEA cell proliferation
GO:0008284 IDA positive regulation of cell proliferation
GO:0008544 IMP epidermis development
GO:0009986 IEA cell surface
GO:0010008 IEA endosome membrane
GO:0010960 IEA magnesium ion homeostasis
GO:0014070 IEA response to organic cyclic compound
GO:0016021 IEA integral component of membrane
GO:0016101 IEA diterpenoid metabolic process
GO:0016301 IDA kinase activity
GO:0016323 IDA basolateral plasma membrane
GO:0016324 IEA apical plasma membrane
GO:0016337 IEA single organismal cell-cell adhesion
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019694 IEA alkanesulfonate metabolic process
GO:0019899 IEA enzyme binding
GO:0019901 IEA protein kinase binding
GO:0019903 IEA protein phosphatase binding
GO:0021795 IMP cerebral cortex cell migration
GO:0023014 IEA signal transduction by phosphorylation
GO:0030139 IDA endocytic vesicle
GO:0030235 IEA nitric-oxide synthase regulator activity
GO:0030324 IEA lung development
GO:0030335 IEA positive regulation of cell migration
GO:0031625 IEA ubiquitin protein ligase binding
GO:0031659 IEA positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0032355 IEA response to estradiol
GO:0032930 IEA positive regulation of superoxide anion generation
GO:0033590 IEA response to cobalamin
GO:0033594 IEA response to hydroxyisoflavone
GO:0033993 IEA response to lipid
GO:0035413 IEA positive regulation of catenin import into nucleus
GO:0035556 IEA intracellular signal transduction
GO:0035690 IEA cellular response to drug
GO:0042127 IGI regulation of cell proliferation
GO:0042177 IEA negative regulation of protein catabolic process
GO:0042327 IEA positive regulation of phosphorylation
GO:0042698 IEA ovulation cycle
GO:0042743 IEA hydrogen peroxide metabolic process
GO:0042802 IEA identical protein binding
GO:0043066 IEA negative regulation of apoptotic process
GO:0043235 ISO receptor complex
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0043586 IEA tongue development
GO:0045121 IEA membrane raft
GO:0045429 IEA positive regulation of nitric oxide biosynthetic process
GO:0045739 IEA positive regulation of DNA repair
GO:0045740 IEA positive regulation of DNA replication
GO:0045907 IEA positive regulation of vasoconstriction
GO:0045909 IEA positive regulation of vasodilation
GO:0045930 IEA negative regulation of mitotic cell cycle
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046777 IDA protein autophosphorylation
GO:0046982 IEA protein heterodimerization activity
GO:0048143 IEA astrocyte activation
GO:0048146 IMP positive regulation of fibroblast proliferation
GO:0048408 IEA epidermal growth factor binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048546 IMP digestive tract morphogenesis
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0048812 IEA neuron projection morphogenesis
GO:0050679 IMP positive regulation of epithelial cell proliferation
GO:0050729 IEA positive regulation of inflammatory response
GO:0050730 IMP regulation of peptidyl-tyrosine phosphorylation
GO:0050999 IEA regulation of nitric-oxide synthase activity
GO:0051015 IEA actin filament binding
GO:0051592 IEA response to calcium ion
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0051968 IEA positive regulation of synaptic transmission, glutamatergic
GO:0060571 IMP morphogenesis of an epithelial fold
GO:0070141 IEA response to UV-A
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0071230 IDA cellular response to amino acid stimulus
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071364 IEA cellular response to epidermal growth factor stimulus
GO:0071392 ISS cellular response to estradiol stimulus
GO:0071549 IEA cellular response to dexamethasone stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000079483 ERBB4 (3 of 3)-201 protein_coding Danio_rerio 8.00141e-43 182
ENST00000275493 EGFR-001 protein_coding Homo_sapiens 0 3685
ENST00000342916 EGFR-003 protein_coding Homo_sapiens 0 1814
ENST00000344576 EGFR-002 protein_coding Homo_sapiens 0 1814
ENST00000420316 EGFR-005 protein_coding Homo_sapiens 0 1147
ENST00000442591 EGFR-201 protein_coding Homo_sapiens 0 1844
ENST00000450046 EGFR-009 protein_coding Homo_sapiens 0 422
ENST00000454757 EGFR-202 protein_coding Homo_sapiens 0 3216
ENST00000455089 EGFR-004 protein_coding Homo_sapiens 0 2844
ENST00000485503 EGFR-010 retained_intron Homo_sapiens 0 329

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