C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: epidermal growth factor receptor
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000275493 EGFR-001 ENSG00000146648 9606 + 7:55019101-55211628 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000275493
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000275493 11.327±0.00 4.313±0.00 3.456±0.00 3.376±1.02 9.046±2.98 6.443±0.04 2.534±1.20 9.665±2.06 8.835±0.75 6.174±1.83 1.289±0.09 3.793±2.31 37.074±5.44 7.314±6.27

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000647 CIL_000647_0001 CGP 7:54752250-55256620

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 NAS MAPK cascade
GO:0000186 IEA activation of MAPKK activity
GO:0000902 IEA cell morphogenesis
GO:0001503 NAS ossification
GO:0001889 IEA liver development
GO:0001892 IEA embryonic placenta development
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0001942 IEA hair follicle development
GO:0001948 IEA glycoprotein binding
GO:0003682 IDA chromatin binding
GO:0003690 NAS double-stranded DNA binding
GO:0004672 IEA protein kinase activity
GO:0004709 NAS MAP kinase kinase kinase activity
GO:0004713 IMP:IEA protein tyrosine kinase activity
GO:0004714 TAS:IEA transmembrane receptor protein tyrosine kinase activity
GO:0004716 IEA receptor signaling protein tyrosine kinase activity
GO:0004871 IEA signal transducer activity
GO:0004888 IDA transmembrane signaling receptor activity
GO:0005006 IDA epidermal growth factor-activated receptor activity
GO:0005102 IEA receptor binding
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005615 NAS extracellular space
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005768 IDA endosome
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0005925 IDA focal adhesion
GO:0006412 IEA translation
GO:0006468 IEA protein phosphorylation
GO:0006950 NAS response to stress
GO:0006970 IEA response to osmotic stress
GO:0006979 IEA response to oxidative stress
GO:0007165 IDA signal transduction
GO:0007166 IDA cell surface receptor signaling pathway
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 IDA epidermal growth factor receptor signaling pathway
GO:0007202 TAS activation of phospholipase C activity
GO:0007411 TAS axon guidance
GO:0007435 IEA salivary gland morphogenesis
GO:0007611 ISS learning or memory
GO:0007623 IEA circadian rhythm
GO:0008283 IDA cell proliferation
GO:0008284 IDA positive regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0008544 IEA epidermis development
GO:0009986 IEA cell surface
GO:0010008 IDA endosome membrane
GO:0010960 IEA magnesium ion homeostasis
GO:0014070 IEA response to organic cyclic compound
GO:0016020 IDA:IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016101 IEA diterpenoid metabolic process
GO:0016301 IEA kinase activity
GO:0016323 IDA basolateral plasma membrane
GO:0016324 IEA apical plasma membrane
GO:0016337 IMP single organismal cell-cell adhesion
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019694 IEA alkanesulfonate metabolic process
GO:0019899 IPI enzyme binding
GO:0019901 IEA protein kinase binding
GO:0019903 IPI protein phosphatase binding
GO:0021795 IEA cerebral cortex cell migration
GO:0023014 IEA signal transduction by phosphorylation
GO:0030122 TAS AP-2 adaptor complex
GO:0030139 IEA endocytic vesicle
GO:0030235 IDA nitric-oxide synthase regulator activity
GO:0030324 IEA lung development
GO:0030335 IMP positive regulation of cell migration
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031659 IDA positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0032355 IEA response to estradiol
GO:0032930 IEA positive regulation of superoxide anion generation
GO:0033590 IEA response to cobalamin
GO:0033594 IEA response to hydroxyisoflavone
GO:0033993 IEA response to lipid
GO:0035413 IMP positive regulation of catenin import into nucleus
GO:0035556 IEA intracellular signal transduction
GO:0035690 IEA cellular response to drug
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042059 TAS negative regulation of epidermal growth factor receptor signaling pathway
GO:0042127 IEA regulation of cell proliferation
GO:0042177 IDA negative regulation of protein catabolic process
GO:0042327 IDA positive regulation of phosphorylation
GO:0042698 IEA ovulation cycle
GO:0042743 IEA hydrogen peroxide metabolic process
GO:0042802 IPI identical protein binding
GO:0043006 TAS activation of phospholipase A2 activity by calcium-mediated signaling
GO:0043066 IMP negative regulation of apoptotic process
GO:0043235 IDA receptor complex
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0043586 IEA tongue development
GO:0045087 TAS innate immune response
GO:0045121 IDA membrane raft
GO:0045429 IDA positive regulation of nitric oxide biosynthetic process
GO:0045739 IDA positive regulation of DNA repair
GO:0045740 IDA positive regulation of DNA replication
GO:0045907 IEA positive regulation of vasoconstriction
GO:0045909 IEA positive regulation of vasodilation
GO:0045930 IEA negative regulation of mitotic cell cycle
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046777 IMP protein autophosphorylation
GO:0046982 IDA protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048143 IEA astrocyte activation
GO:0048146 IEA positive regulation of fibroblast proliferation
GO:0048408 IEA epidermal growth factor binding
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048546 IEA digestive tract morphogenesis
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0048812 IEA neuron projection morphogenesis
GO:0050679 IDA positive regulation of epithelial cell proliferation
GO:0050729 IEA positive regulation of inflammatory response
GO:0050730 IMP regulation of peptidyl-tyrosine phosphorylation
GO:0050999 IDA regulation of nitric-oxide synthase activity
GO:0051015 IDA actin filament binding
GO:0051205 TAS protein insertion into membrane
GO:0051592 IEA response to calcium ion
GO:0051897 IMP positive regulation of protein kinase B signaling
GO:0051968 IEA positive regulation of synaptic transmission, glutamatergic
GO:0060571 IEA morphogenesis of an epithelial fold
GO:0070141 IDA response to UV-A
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0070435 ISS Shc-EGFR complex
GO:0071230 IEA cellular response to amino acid stimulus
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071364 ISS cellular response to epidermal growth factor stimulus
GO:0071392 IDA cellular response to estradiol stimulus
GO:0071549 IEA cellular response to dexamethasone stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000020329 Egfr-001 protein_coding Mus_musculus 0 3685
ENSMUST00000102884 Egfr-002 protein_coding Mus_musculus 0 1844
ENSMUST00000138518 Egfr-004 processed_transcript Mus_musculus 0 673
ENSDART00000092118 erbb4a-002 protein_coding Danio_rerio 0 333
ENSDART00000145822 erbb4a-001 protein_coding Danio_rerio 0 333
ENSDART00000127426 protein_coding Danio_rerio 0 287

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