C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: PTK2 protein tyrosine kinase 2 beta
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000022622 Ptk2b-002 ENSMUSG00000059456 10090 - 14:66153257-66281052 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000022622
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000022622 7.787±0.60 1.810±0.32 12.777±1.46 0.207±0.00 8.588±1.41 13.562±2.27 2.045±0.09 13.455±0.78 4.341±3.12 3.352±1.49 10.773±2.45 2.693±0.32 1.323±0.15

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000OS CIL_0000OS_0003 CGP 14:66140960-66281052

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000302 IEA response to reactive oxygen species
GO:0001525 IEA angiogenesis
GO:0001556 IEA oocyte maturation
GO:0001666 IEA response to hypoxia
GO:0001954 ISS positive regulation of cell-matrix adhesion
GO:0002040 IMP sprouting angiogenesis
GO:0002315 IMP marginal zone B cell differentiation
GO:0004672 IDA protein kinase activity
GO:0004683 ISS calmodulin-dependent protein kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0004972 ISS N-methyl-D-aspartate selective glutamate receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0005925 IEA focal adhesion
GO:0005938 IEA cell cortex
GO:0006468 IDA protein phosphorylation
GO:0006968 ISS cellular defense response
GO:0006970 IEA response to osmotic stress
GO:0007015 IEA actin filament organization
GO:0007155 IEA cell adhesion
GO:0007166 ISS cell surface receptor signaling pathway
GO:0007172 IEA signal complex assembly
GO:0007173 IEA epidermal growth factor receptor signaling pathway
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007229 ISS integrin-mediated signaling pathway
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0008360 IMP regulation of cell shape
GO:0009612 IEA response to mechanical stimulus
GO:0009725 IEA response to hormone
GO:0009749 IEA response to glucose
GO:0010226 IEA response to lithium ion
GO:0010243 IEA response to organonitrogen compound
GO:0010595 IMP positive regulation of endothelial cell migration
GO:0010656 IEA negative regulation of muscle cell apoptotic process
GO:0010752 IMP regulation of cGMP-mediated signaling
GO:0010758 IMP regulation of macrophage chemotaxis
GO:0010976 IEA positive regulation of neuron projection development
GO:0014009 IEA glial cell proliferation
GO:0014069 ISS postsynaptic density
GO:0017146 ISS N-methyl-D-aspartate selective glutamate receptor complex
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0030027 ISS lamellipodium
GO:0030154 IEA cell differentiation
GO:0030155 ISS regulation of cell adhesion
GO:0030279 IEA negative regulation of ossification
GO:0030307 IEA positive regulation of cell growth
GO:0030335 IEA positive regulation of cell migration
GO:0030424 IEA axon
GO:0030425 ISS dendrite
GO:0030426 ISS growth cone
GO:0030502 IMP negative regulation of bone mineralization
GO:0030826 IMP regulation of cGMP biosynthetic process
GO:0030838 ISS positive regulation of actin filament polymerization
GO:0031175 IEA neuron projection development
GO:0032403 IEA protein complex binding
GO:0032863 IEA activation of Rac GTPase activity
GO:0032960 IMP regulation of inositol trisphosphate biosynthetic process
GO:0033209 IEA tumor necrosis factor-mediated signaling pathway
GO:0035235 ISS ionotropic glutamate receptor signaling pathway
GO:0035902 IEA response to immobilization stress
GO:0038083 ISS peptidyl-tyrosine autophosphorylation
GO:0042220 IEA response to cocaine
GO:0042493 IEA response to drug
GO:0042542 IEA response to hydrogen peroxide
GO:0042976 IEA activation of Janus kinase activity
GO:0043025 ISS neuronal cell body
GO:0043066 IMP negative regulation of apoptotic process
GO:0043149 IEA stress fiber assembly
GO:0043267 IEA negative regulation of potassium ion transport
GO:0043423 IEA 3-phosphoinositide-dependent protein kinase binding
GO:0043507 IEA positive regulation of JUN kinase activity
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0043534 IEA blood vessel endothelial cell migration
GO:0043552 IMP positive regulation of phosphatidylinositol 3-kinase activity
GO:0044297 ISS cell body
GO:0045121 IEA membrane raft
GO:0045428 IMP regulation of nitric oxide biosynthetic process
GO:0045453 IMP bone resorption
GO:0045471 IEA response to ethanol
GO:0045638 IEA negative regulation of myeloid cell differentiation
GO:0045727 IEA positive regulation of translation
GO:0045766 IMP positive regulation of angiogenesis
GO:0045860 ISS positive regulation of protein kinase activity
GO:0046330 ISS positive regulation of JNK cascade
GO:0048010 IMP vascular endothelial growth factor receptor signaling pathway
GO:0048041 IEA focal adhesion assembly
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050848 IMP regulation of calcium-mediated signaling
GO:0051000 IMP positive regulation of nitric-oxide synthase activity
GO:0051279 IMP regulation of release of sequestered calcium ion into cytosol
GO:0051591 IEA response to cAMP
GO:0051592 IEA response to calcium ion
GO:0051968 ISS positive regulation of synaptic transmission, glutamatergic
GO:0060291 ISS long-term synaptic potentiation
GO:0070098 IMP chemokine-mediated signaling pathway
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0071300 IEA cellular response to retinoic acid
GO:0097440 ISS apical dendrite
GO:2000058 IEA regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000060 IMP positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000114 IMP regulation of establishment of cell polarity
GO:2000249 IMP regulation of actin cytoskeleton reorganization
GO:2000310 ISS regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000379 IEA positive regulation of reactive oxygen species metabolic process
GO:2000463 ISS positive regulation of excitatory postsynaptic membrane potential
GO:2000538 IMP positive regulation of B cell chemotaxis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000346049 PTK2B-001 protein_coding Homo_sapiens 0 3988
ENST00000397497 PTK2B-003 protein_coding Homo_sapiens 0 1797
ENST00000397501 PTK2B-009 protein_coding Homo_sapiens 0 3988
ENST00000412793 PTK2B-007 protein_coding Homo_sapiens 0 861
ENST00000420218 PTK2B-201 protein_coding Homo_sapiens 0 2898
ENST00000461615 PTK2B-006 retained_intron Homo_sapiens 0 320
ENST00000517339 PTK2B-002 protein_coding Homo_sapiens 0 2887
ENST00000519512 PTK2B-011 protein_coding Homo_sapiens 0 488
ENST00000521000 PTK2B-016 retained_intron Homo_sapiens 0 444
ENST00000521164 PTK2B-014 protein_coding Homo_sapiens 0 446
ENST00000522245 PTK2B-017 retained_intron Homo_sapiens 0 322
ENST00000522517 PTK2B-015 protein_coding Homo_sapiens 0 769

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