C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: sterol regulatory element binding factor 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000023100 Srebf2-201 ENSMUSG00000022463 10090 + 15:82147266-82205376 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000023100
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000023100 15.594±2.41 42.608±7.17 23.338±0.62 39.770±12.73 27.536±12.09 79.080±4.81 6.686±0.81 26.748±3.17 20.083±3.70 62.850±2.37 2.496±0.92 43.557±14.98 24.594±11.62 5.661±2.94

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004BD CIL_0004BD_0002 CGP 15:82127922-82205376
CIL_0004BE CIL_0004BE_0002 CGP 15:82147266-82212815

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005730 IEA nucleolus
GO:0005737 IDA cytoplasm
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0008022 IEA protein C-terminus binding
GO:0008203 IEA cholesterol metabolic process
GO:0010886 IEA positive regulation of cholesterol storage
GO:0016020 IDA membrane
GO:0031410 IEA cytoplasmic vesicle
GO:0032937 IEA SREBP-SCAP-Insig complex
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IEA protein dimerization activity
GO:0055098 IEA response to low-density lipoprotein particle
GO:0070888 IEA E-box binding
GO:0072368 IEA regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
GO:0090370 IEA negative regulation of cholesterol efflux
GO:2000188 IGI regulation of cholesterol homeostasis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000361204 SREBF2-001 protein_coding Homo_sapiens 0 3995
ENST00000424354 SREBF2-002 nonsense_mediated_decay Homo_sapiens 0 2032
ENST00000435061 SREBF2-005 protein_coding Homo_sapiens 0 510
ENST00000462539 SREBF2-008 retained_intron Homo_sapiens 0 848
ENST00000463741 SREBF2-006 retained_intron Homo_sapiens 0 250
ENST00000491541 SREBF2-003 processed_transcript Homo_sapiens 0 815
ENST00000612482 SREBF2-201 protein_coding Homo_sapiens 0 2067

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