C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: sterol regulatory element binding transcription factor 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000361204 SREBF2-001 ENSG00000198911 9606 + 22:41833105-41907308 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000361204
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000361204 12.759±0.00 21.335±0.00 24.556±14.31 9.080±6.24 10.495±6.40 10.250±9.13 11.843±8.32 11.966±9.91 17.854±14.00 7.923±7.53 24.757±13.66 21.422±2.07 14.850±6.95

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004BD CIL_0004BD_0001 CGP 22:41800679-41907308
CIL_0004BE CIL_0004BE_0001 CGP 22:41833079-41914667

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000139 TAS Golgi membrane
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677 IEA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006629 TAS lipid metabolic process
GO:0008022 IPI protein C-terminus binding
GO:0008203 IEA cholesterol metabolic process
GO:0010886 IDA positive regulation of cholesterol storage
GO:0016020 IEA membrane
GO:0031410 IEA cytoplasmic vesicle
GO:0032937 IDA SREBP-SCAP-Insig complex
GO:0044212 IEA transcription regulatory region DNA binding
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IEA protein dimerization activity
GO:0055098 IEP response to low-density lipoprotein particle
GO:0070888 IDA E-box binding
GO:0071499 NAS cellular response to laminar fluid shear stress
GO:0072368 IDA regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
GO:0090370 IDA negative regulation of cholesterol efflux
GO:2000188 IEA regulation of cholesterol homeostasis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000023100 Srebf2-201 protein_coding Mus_musculus 0 3995

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