C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: neurotrophic tyrosine kinase, receptor, type 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000029712 Ntrk1-201 ENSMUSG00000028072 10090 - 3:87778244-87795162 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000029712
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000029712 0.641±0.68 5.597±2.53 0.786±0.21 0.877±0.29 1.578±0.90 0.089±0.04 0.157±0.02 1.453±0.58 0.069±0.04 0.314±0.18 0.039±0.01 1.430±0.78 0.123±0.17 0.281±0.11

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000850 CIL_000850_0002 VISTA 3:87682625-88286876
CIL_0005I5 CIL_0005I5_0002 CGP 3:87778244-87816101

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004713 ISO protein tyrosine kinase activity
GO:0004714 ISS transmembrane receptor protein tyrosine kinase activity
GO:0005166 IEA neurotrophin p75 receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0005769 ISS early endosome
GO:0005770 ISS late endosome
GO:0005886 ISS plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0006468 IDA protein phosphorylation
GO:0007399 IDA nervous system development
GO:0007411 IEA axon guidance
GO:0007568 IEA aging
GO:0007611 IEA learning or memory
GO:0007623 IEP circadian rhythm
GO:0008285 ISS negative regulation of cell proliferation
GO:0009314 IEA response to radiation
GO:0009986 ISO cell surface
GO:0010465 ISS nerve growth factor receptor activity
GO:0010623 ISS developmental programmed cell death
GO:0010976 ISS positive regulation of neuron projection development
GO:0014823 IEA response to activity
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019233 IEA sensory perception of pain
GO:0021553 IEA olfactory nerve development
GO:0030183 IMP B cell differentiation
GO:0030424 IDA axon
GO:0030425 IEA dendrite
GO:0031410 IEA cytoplasmic vesicle
GO:0031667 IEA response to nutrient levels
GO:0032320 ISS positive regulation of Ras GTPase activity
GO:0035094 IEA response to nicotine
GO:0038180 ISS nerve growth factor signaling pathway
GO:0042490 IMP mechanoreceptor differentiation
GO:0042493 IEA response to drug
GO:0042803 ISS protein homodimerization activity
GO:0043025 IEA neuronal cell body
GO:0043068 ISS positive regulation of programmed cell death
GO:0043234 ISS protein complex
GO:0043235 ISO receptor complex
GO:0043524 IGI negative regulation of neuron apoptotic process
GO:0045471 IEA response to ethanol
GO:0045766 IEA positive regulation of angiogenesis
GO:0046579 ISS positive regulation of Ras protein signal transduction
GO:0046777 ISS protein autophosphorylation
GO:0046875 IEA ephrin receptor binding
GO:0048011 ISS neurotrophin TRK receptor signaling pathway
GO:0048406 ISS nerve growth factor binding
GO:0048485 IMP sympathetic nervous system development
GO:0048678 IEA response to axon injury
GO:0050965 IEA detection of temperature stimulus involved in sensory perception of pain
GO:0050966 IEA detection of mechanical stimulus involved in sensory perception of pain
GO:0051092 ISS positive regulation of NF-kappaB transcription factor activity
GO:0051599 IEA response to hydrostatic pressure
GO:0051602 IEA response to electrical stimulus
GO:0051968 IEA positive regulation of synaptic transmission, glutamatergic
GO:0060009 IEA Sertoli cell development
GO:0060385 IMP axonogenesis involved in innervation
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0071316 IEA cellular response to nicotine
GO:0071363 ISO cellular response to growth factor stimulus
GO:1901215 IEA negative regulation of neuron death
GO:1990090 ISS cellular response to nerve growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000355254 NTRK3-201 protein_coding Homo_sapiens 0 346
ENST00000357724 NTRK3-202 protein_coding Homo_sapiens 5.60519e-45 187
ENST00000358660 NTRK1-006 protein_coding Homo_sapiens 0 2355
ENST00000360948 NTRK3-203 protein_coding Homo_sapiens 5.60519e-45 187
ENST00000368196 NTRK1-001 protein_coding Homo_sapiens 0 2396
ENST00000392302 NTRK1-004 protein_coding Homo_sapiens 0 2239
ENST00000394480 NTRK3-001 protein_coding Homo_sapiens 0 346
ENST00000497019 NTRK1-002 nonsense_mediated_decay Homo_sapiens 0 1698
ENST00000524377 NTRK1-007 protein_coding Homo_sapiens 0 2499
ENST00000530298 NTRK1-005 retained_intron Homo_sapiens 0 1175
ENST00000531606 NTRK1-011 processed_transcript Homo_sapiens 0 219
ENST00000533630 NTRK1-009 retained_intron Homo_sapiens 0 287
ENST00000534682 NTRK1-010 retained_intron Homo_sapiens 0 488
ENST00000557856 NTRK3-004 protein_coding Homo_sapiens 0 346

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