C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: mitogen-activated protein kinase kinase 5
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000034920 Map2k5-201 ENSMUSG00000058444 10090 - 9:63163769-63377902 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000034920
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000034920 13.247±0.37 33.349±4.21 9.187±0.70 18.543±2.02 19.498±9.15 12.960±3.51 7.596±2.15 11.966±1.05 8.125±3.19 15.259±4.36 5.711±0.36 24.913±7.85 16.295±8.12 16.051±4.91

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008FO CIL_0008FO_0002 VISTA 9:62808235-63410238
CIL_00098T CIL_00098T_0002 VISTA 9:62831587-63433435
CIL_0008DX CIL_0008DX_0002 VISTA 9:62876076-63477276
CIL_0004FE CIL_0004FE_0002 CGP 9:63138170-63377902

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000165 IMP MAPK cascade
GO:0000187 IEA activation of MAPK activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005819 IDA spindle
GO:0005829 IEA cytosol
GO:0007507 IMP heart development
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030307 IEA positive regulation of cell growth
GO:0032088 IEA negative regulation of NF-kappaB transcription factor activity
GO:0034115 IEA negative regulation of heterotypic cell-cell adhesion
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045415 IEA negative regulation of interleukin-8 biosynthetic process
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0051247 IEA positive regulation of protein metabolic process
GO:0060761 IEA negative regulation of response to cytokine stimulus
GO:0070375 IEA ERK5 cascade
GO:0071363 IEA cellular response to growth factor stimulus
GO:0090051 IEA negative regulation of cell migration involved in sprouting angiogenesis
GO:2000342 IEA negative regulation of chemokine (C-X-C motif) ligand 2 production
GO:2001240 IEA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000178640 MAP2K5-001 protein_coding Homo_sapiens 0 1892
ENST00000340972 MAP2K5-002 protein_coding Homo_sapiens 0 1009
ENST00000354498 MAP2K5-005 protein_coding Homo_sapiens 0 1631
ENST00000395476 MAP2K5-013 protein_coding Homo_sapiens 0 1423
ENST00000439036 MAP2K5-003 protein_coding Homo_sapiens 0 527
ENST00000557869 MAP2K5-009 protein_coding Homo_sapiens 2e-36 156
ENST00000558021 MAP2K5-008 retained_intron Homo_sapiens 2e-36 156
ENST00000558274 MAP2K5-010 processed_transcript Homo_sapiens 0 278
ENST00000558392 MAP2K5-007 retained_intron Homo_sapiens 0 1373
ENST00000559262 MAP2K5-006 protein_coding Homo_sapiens 0 699
ENST00000560086 MAP2K5-012 processed_transcript Homo_sapiens 0.00000005 62
ENST00000560591 MAP2K5-004 processed_transcript Homo_sapiens 0 1129

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