C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: breast cancer 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000044620 Brca2-201 ENSMUSG00000041147 10090 + 5:150522630-150569746 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000044620
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000044620 0.249±0.11 0.431±0.11 0.202±0.08 1.050±0.53 0.116±0.05 0.243±0.07 0.119±0.03 0.144±0.06 0.865±0.85 0.161±0.07 0.060±0.03 0.940±0.46 0.781±0.48 1.263±0.22

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000V0 CIL_0000V0_0002 CGP 5:150507055-150569746
CIL_0000UZ CIL_0000UZ_0002 CGP 5:150522630-150594525

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000724 IMP double-strand break repair via homologous recombination
GO:0000910 IEA cytokinesis
GO:0001556 IMP oocyte maturation
GO:0001833 IMP inner cell mass cell proliferation
GO:0002020 IEA protease binding
GO:0003697 IBA single-stranded DNA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005813 ISS centrosome
GO:0006289 IEA nucleotide-excision repair
GO:0006302 IMP double-strand break repair
GO:0006355 IBA regulation of transcription, DNA-templated
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0006978 IMP DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007141 IMP male meiosis I
GO:0007283 IMP spermatogenesis
GO:0007420 IMP brain development
GO:0007569 IMP cell aging
GO:0008283 IMP cell proliferation
GO:0008585 IMP female gonad development
GO:0008630 IGI intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010165 IMP response to X-ray
GO:0010225 IMP response to UV-C
GO:0010332 IMP response to gamma radiation
GO:0010484 IEA H3 histone acetyltransferase activity
GO:0010485 IEA H4 histone acetyltransferase activity
GO:0030097 IMP hemopoiesis
GO:0030141 IEA secretory granule
GO:0032465 IMP regulation of cytokinesis
GO:0033593 IEA BRCA2-MAGE-D1 complex
GO:0033600 IEA negative regulation of mammary gland epithelial cell proliferation
GO:0042127 IBA regulation of cell proliferation
GO:0042771 IMP intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043009 IMP chordate embryonic development
GO:0043015 IBA gamma-tubulin binding
GO:0043234 IEA protein complex
GO:0043966 IEA histone H3 acetylation
GO:0043967 IEA histone H4 acetylation
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045931 IMP positive regulation of mitotic cell cycle
GO:0048478 IMP replication fork protection
GO:0051276 IMP chromosome organization
GO:0051298 IBA centrosome duplication

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000380152 BRCA2-001 protein_coding Homo_sapiens 0 1808
ENST00000544455 BRCA2-201 protein_coding Homo_sapiens 0 1808
ENST00000614259 BRCA2-004 processed_transcript Homo_sapiens 0 686

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