C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: transforming growth factor, beta 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000045288 Tgfb2-201 ENSMUSG00000039239 10090 - 1:186623186-186705992 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000045288
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000045288 0.900±0.58 0.643±0.08 2.722±0.80 1.432±0.38 0.559±0.35 0.878±0.47 0.675±0.09 0.425±0.30 0.142±0.13 1.830±0.09 1.526±0.32 1.254±0.89 2.349±1.00 0.108±0.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000405 CIL_000405_0002 CGP 1:186087731-186705992
CIL_00086U CIL_00086U_0002 VISTA 1:186608316-187210077
CIL_00086S CIL_00086S_0002 VISTA 1:186622310-187223505

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000902 ISS cell morphogenesis
GO:0001501 IMP skeletal system development
GO:0001502 IGI cartilage condensation
GO:0001540 ISS beta-amyloid binding
GO:0001568 IMP blood vessel development
GO:0001654 ISS eye development
GO:0001666 ISS response to hypoxia
GO:0001837 ISS epithelial to mesenchymal transition
GO:0001942 ISS hair follicle development
GO:0001974 IMP blood vessel remodeling
GO:0003007 ISS heart morphogenesis
GO:0003151 TAS outflow tract morphogenesis
GO:0003179 IMP heart valve morphogenesis
GO:0003214 TAS cardiac left ventricle morphogenesis
GO:0003215 TAS cardiac right ventricle morphogenesis
GO:0004702 ISS receptor signaling protein serine/threonine kinase activity
GO:0005102 ISS receptor binding
GO:0005114 ISS type II transforming growth factor beta receptor binding
GO:0005160 ISS transforming growth factor beta receptor binding
GO:0005515 IPI protein binding
GO:0005576 ISS extracellular region
GO:0005615 IDA extracellular space
GO:0005768 IDA endosome
GO:0006468 ISS protein phosphorylation
GO:0007050 ISS cell cycle arrest
GO:0007179 ISS transforming growth factor beta receptor signaling pathway
GO:0007184 ISS SMAD protein import into nucleus
GO:0007411 IMP axon guidance
GO:0007435 IEA salivary gland morphogenesis
GO:0007507 ISS heart development
GO:0008083 TAS growth factor activity
GO:0008219 ISS cell death
GO:0008284 ISS positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0008347 ISS glial cell migration
GO:0009611 IEA response to wounding
GO:0010002 ISS cardioblast differentiation
GO:0010628 IDA positive regulation of gene expression
GO:0010634 ISS positive regulation of epithelial cell migration
GO:0010693 ISS negative regulation of alkaline phosphatase activity
GO:0010718 ISS positive regulation of epithelial to mesenchymal transition
GO:0010936 ISS negative regulation of macrophage cytokine production
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016049 IEA cell growth
GO:0016477 ISS cell migration
GO:0022601 IEA menstrual cycle phase
GO:0023014 ISS signal transduction by phosphorylation
GO:0030097 IMP hemopoiesis
GO:0030198 IMP extracellular matrix organization
GO:0030199 ISS collagen fibril organization
GO:0030307 ISS positive regulation of cell growth
GO:0030308 IEA negative regulation of cell growth
GO:0030424 IDA axon
GO:0030593 ISS neutrophil chemotaxis
GO:0031012 ISS extracellular matrix
GO:0031069 IMP hair follicle morphogenesis
GO:0032147 ISS activation of protein kinase activity
GO:0032570 ISS response to progesterone
GO:0032874 ISS positive regulation of stress-activated MAPK cascade
GO:0032909 ISS regulation of transforming growth factor beta2 production
GO:0033630 ISS positive regulation of cell adhesion mediated by integrin
GO:0042060 ISS wound healing
GO:0042416 IMP dopamine biosynthetic process
GO:0042493 ISS response to drug
GO:0042637 ISS catagen
GO:0042803 ISS protein homodimerization activity
GO:0042981 IMP regulation of apoptotic process
GO:0043025 IDA neuronal cell body
GO:0043525 ISS positive regulation of neuron apoptotic process
GO:0045216 ISS cell-cell junction organization
GO:0045617 NAS negative regulation of keratinocyte differentiation
GO:0045726 ISS positive regulation of integrin biosynthetic process
GO:0045778 IEA positive regulation of ossification
GO:0045787 IMP positive regulation of cell cycle
GO:0045823 ISS positive regulation of heart contraction
GO:0048103 IDA somatic stem cell division
GO:0048566 IEA embryonic digestive tract development
GO:0048663 IDA neuron fate commitment
GO:0048666 IMP neuron development
GO:0050680 ISS negative regulation of epithelial cell proliferation
GO:0050714 ISS positive regulation of protein secretion
GO:0050778 ISS positive regulation of immune response
GO:0051781 IEA positive regulation of cell division
GO:0051795 ISS positive regulation of catagen
GO:0051891 ISS positive regulation of cardioblast differentiation
GO:0060038 ISS cardiac muscle cell proliferation
GO:0060317 ISS cardiac epithelial to mesenchymal transition
GO:0060325 IEP face morphogenesis
GO:0060389 IDA pathway-restricted SMAD protein phosphorylation
GO:0060412 TAS ventricular septum morphogenesis
GO:0061037 IMP negative regulation of cartilage development
GO:0070237 IDA positive regulation of activation-induced cell death of T cells
GO:0097191 ISS extrinsic apoptotic signaling pathway
GO:1903053 IMP regulation of extracellular matrix organization
GO:2001241 IDA positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000366929 TGFB2-002 protein_coding Homo_sapiens 0 1703
ENST00000366930 TGFB2-001 protein_coding Homo_sapiens 0 2187
ENST00000479322 TGFB2-004 processed_transcript Homo_sapiens 0 1046
ENST00000488793 TGFB2-003 processed_transcript Homo_sapiens 0 351

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