C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: c-abl oncogene 1, non-receptor tyrosine kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000075759 Abl1-001 ENSMUSG00000026842 10090 + 2:31689295-31803541 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000075759
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000075759 20.136±5.30 29.778±3.43 18.495±0.82 14.772±5.37 18.146±5.06 28.045±3.41 7.330±0.99 11.498±1.26 5.865±1.70 19.791±0.26 4.635±0.64 31.608±9.85 10.076±5.58 11.634±4.49

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000936 CIL_000936_0002 VISTA 2:31199311-31800827
CIL_0008XQ CIL_0008XQ_0002 VISTA 2:31340644-31941311
CIL_0007CW CIL_0007CW_0003 CGP 2:31670715-31804227
CIL_0006I2 CIL_0006I2_0002 CGP 2:31688376-31810580

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0001922 IMP B-1 B cell homeostasis
GO:0002322 IMP B cell proliferation involved in immune response
GO:0002333 IMP transitional one stage B cell differentiation
GO:0003677 IEA DNA binding
GO:0004672 IDA protein kinase activity
GO:0004713 IMP protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IDA ATP binding
GO:0005634 IDA nucleus
GO:0005730 IEA nucleolus
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 ISA cytosol
GO:0006281 IEA DNA repair
GO:0006909 IMP phagocytosis
GO:0006914 IEA autophagy
GO:0006915 IEA apoptotic process
GO:0006974 ISS cellular response to DNA damage stimulus
GO:0006975 IEA DNA damage induced protein phosphorylation
GO:0006979 IMP response to oxidative stress
GO:0007173 IGI epidermal growth factor receptor signaling pathway
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0008022 IEA protein C-terminus binding
GO:0015629 IDA actin cytoskeleton
GO:0016301 IDA kinase activity
GO:0017124 IEA SH3 domain binding
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019904 IPI protein domain specific binding
GO:0019905 IEA syntaxin binding
GO:0021587 IGI cerebellum morphogenesis
GO:0022408 IGI negative regulation of cell-cell adhesion
GO:0030035 IDA microspike assembly
GO:0030036 IDA actin cytoskeleton organization
GO:0030145 IDA manganese ion binding
GO:0030514 IMP negative regulation of BMP signaling pathway
GO:0031252 IDA cell leading edge
GO:0032956 IGI regulation of actin cytoskeleton organization
GO:0033690 IMP positive regulation of osteoblast proliferation
GO:0034446 IDA substrate adhesion-dependent cell spreading
GO:0042100 IMP B cell proliferation
GO:0042770 ISS signal transduction in response to DNA damage
GO:0043065 IMP positive regulation of apoptotic process
GO:0043123 IGI positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 IMP negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045930 IDA negative regulation of mitotic cell cycle
GO:0045931 IGI positive regulation of mitotic cell cycle
GO:0046632 IGI alpha-beta T cell differentiation
GO:0048008 IMP platelet-derived growth factor receptor signaling pathway
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048536 IMP spleen development
GO:0048538 IMP thymus development
GO:0048668 IMP collateral sprouting
GO:0050731 ISS positive regulation of peptidyl-tyrosine phosphorylation
GO:0050798 IMP activated T cell proliferation
GO:0050853 IMP B cell receptor signaling pathway
GO:0050885 IGI neuromuscular process controlling balance
GO:0051015 IDA actin filament binding
GO:0051019 IEA mitogen-activated protein kinase binding
GO:0051281 IGI positive regulation of release of sequestered calcium ion into cytosol
GO:0051353 IEA positive regulation of oxidoreductase activity
GO:0051444 IEA negative regulation of ubiquitin-protein transferase activity
GO:0051726 IDA regulation of cell cycle
GO:0060020 IGI Bergmann glial cell differentiation
GO:0070064 ISS proline-rich region binding
GO:0070373 IMP negative regulation of ERK1 and ERK2 cascade
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0071222 IMP cellular response to lipopolysaccharide
GO:0071901 IEA negative regulation of protein serine/threonine kinase activity
GO:0090135 IMP actin filament branching
GO:1900042 IGI positive regulation of interleukin-2 secretion
GO:1900275 IEA negative regulation of phospholipase C activity
GO:1901216 IMP positive regulation of neuron death
GO:1902715 IGI positive regulation of interferon-gamma secretion
GO:1903053 IGI regulation of extracellular matrix organization
GO:2000096 IGI positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000352 IGI negative regulation of endothelial cell apoptotic process
GO:2000772 IGI regulation of cellular senescence
GO:2000773 IGI negative regulation of cellular senescence
GO:2001020 IEA regulation of response to DNA damage stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000041697 abl2-001 protein_coding Danio_rerio 0 1094
ENSDART00000138548 abl2-002 protein_coding Danio_rerio 0 1094
ENST00000318560 ABL1-001 protein_coding Homo_sapiens 0 3258
ENST00000372348 ABL1-002 protein_coding Homo_sapiens 0 3517

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