C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: ABL proto-oncogene 1, non-receptor tyrosine kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000372348 ABL1-002 ENSG00000097007 9606 + 9:130713946-130885683 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBreastColonHeartLiverLungOvaryENST00000372348
Transcript ID Bladder Breast Colon Heart Liver Lung Ovary
ENST00000372348 1.004±0.00 2.813±0.00 2.202±0.00 0.876±0.00 3.065±0.00 1.102±0.00 2.014±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000936 CIL_000936_0001 VISTA 9:130178260-130779710
CIL_0008XQ CIL_0008XQ_0001 VISTA 9:130365168-130965841
CIL_0007CW CIL_0007CW_0002 CGP 9:130693721-130887675
CIL_0006I2 CIL_0006I2_0001 CGP 9:130713946-130896812

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0001922 IEA B-1 B cell homeostasis
GO:0002322 IEA B cell proliferation involved in immune response
GO:0002333 IEA transitional one stage B cell differentiation
GO:0003677 NAS DNA binding
GO:0003785 TAS actin monomer binding
GO:0004515 TAS nicotinate-nucleotide adenylyltransferase activity
GO:0004672 IDA:IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004715 IDA:IEA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005634 IDA nucleus
GO:0005730 IDA nucleolus
GO:0005737 TAS cytoplasm
GO:0005739 NAS mitochondrion
GO:0005829 IDA cytosol
GO:0006298 TAS mismatch repair
GO:0006355 TAS regulation of transcription, DNA-templated
GO:0006464 NAS cellular protein modification process
GO:0006468 IEA protein phosphorylation
GO:0006909 IEA phagocytosis
GO:0006914 IEA autophagy
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0006975 IDA DNA damage induced protein phosphorylation
GO:0006979 IGI response to oxidative stress
GO:0007050 TAS cell cycle arrest
GO:0007067 TAS mitotic nuclear division
GO:0007155 IEA cell adhesion
GO:0007173 IEA epidermal growth factor receptor signaling pathway
GO:0007204 IMP positive regulation of cytosolic calcium ion concentration
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008022 IPI protein C-terminus binding
GO:0008630 TAS intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010506 TAS regulation of autophagy
GO:0015629 TAS actin cytoskeleton
GO:0016020 IEA membrane
GO:0016301 IEA kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017124 IPI SH3 domain binding
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019904 IEA protein domain specific binding
GO:0019905 IPI syntaxin binding
GO:0021587 IEA cerebellum morphogenesis
GO:0022408 IEA negative regulation of cell-cell adhesion
GO:0030035 IEA microspike assembly
GO:0030036 ISS actin cytoskeleton organization
GO:0030100 TAS regulation of endocytosis
GO:0030145 IDA manganese ion binding
GO:0030155 TAS regulation of cell adhesion
GO:0030514 IEA negative regulation of BMP signaling pathway
GO:0031252 IEA cell leading edge
GO:0032956 IEA regulation of actin cytoskeleton organization
GO:0033690 IEA positive regulation of osteoblast proliferation
GO:0034446 IEA substrate adhesion-dependent cell spreading
GO:0034599 TAS cellular response to oxidative stress
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042100 IEA B cell proliferation
GO:0042692 TAS muscle cell differentiation
GO:0042770 IDA signal transduction in response to DNA damage
GO:0043065 IDA positive regulation of apoptotic process
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 IEA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 TAS innate immune response
GO:0045930 IEA negative regulation of mitotic cell cycle
GO:0045931 IEA positive regulation of mitotic cell cycle
GO:0046632 IEA alpha-beta T cell differentiation
GO:0048008 IEA platelet-derived growth factor receptor signaling pathway
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048536 IEA spleen development
GO:0048538 IEA thymus development
GO:0048668 IEA collateral sprouting
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050798 IEA activated T cell proliferation
GO:0050853 IEA B cell receptor signaling pathway
GO:0050885 IEA neuromuscular process controlling balance
GO:0051015 IEA actin filament binding
GO:0051019 IPI mitogen-activated protein kinase binding
GO:0051149 TAS positive regulation of muscle cell differentiation
GO:0051281 IEA positive regulation of release of sequestered calcium ion into cytosol
GO:0051353 IDA positive regulation of oxidoreductase activity
GO:0051444 IDA negative regulation of ubiquitin-protein transferase activity
GO:0051726 IEA regulation of cell cycle
GO:0051882 TAS mitochondrial depolarization
GO:0060020 IEA Bergmann glial cell differentiation
GO:0070064 IDA proline-rich region binding
GO:0070373 IEA negative regulation of ERK1 and ERK2 cascade
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071901 IDA negative regulation of protein serine/threonine kinase activity
GO:0090135 IEA actin filament branching
GO:1900042 IEA positive regulation of interleukin-2 secretion
GO:1900275 IMP negative regulation of phospholipase C activity
GO:1901216 IEA positive regulation of neuron death
GO:1902715 IEA positive regulation of interferon-gamma secretion
GO:1903053 IEA regulation of extracellular matrix organization
GO:1903351 TAS cellular response to dopamine
GO:2000096 IEA positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000145 TAS regulation of cell motility
GO:2000249 TAS regulation of actin cytoskeleton reorganization
GO:2000352 IEA negative regulation of endothelial cell apoptotic process
GO:2000772 IEA regulation of cellular senescence
GO:2000773 IEA negative regulation of cellular senescence
GO:2001020 IDA regulation of response to DNA damage stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000075759 Abl1-001 protein_coding Mus_musculus 0 3517
ENSMUST00000028190 Abl1-008 protein_coding Mus_musculus 0 3249
ENSMUST00000142554 Abl1-007 processed_transcript Mus_musculus 0 2228
ENSDART00000005516 abl1-201 protein_coding Danio_rerio 0 1328
ENSDART00000149910 abl1-001 protein_coding Danio_rerio 0 1328
ENSDART00000148626 abl1-002 protein_coding Danio_rerio 0 1328
ENSMUST00000127714 Abl1-010 processed_transcript Mus_musculus 0 675
ENSMUST00000124089 Abl1-009 protein_coding Mus_musculus 0 399
ENSMUST00000135233 Abl1-005 processed_transcript Mus_musculus 0 399
ENSMUST00000124726 Abl1-011 processed_transcript Mus_musculus 0 255

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