C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: bone morphogenetic protein receptor, type II (serine/threonine kinase)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000087435 Bmpr2-001 ENSMUSG00000067336 10090 + 1:59763400-59879014 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000087435
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000087435 7.600±1.84 8.929±1.64 2.572±0.81 5.622±2.18 5.610±0.87 3.701±0.47 5.924±0.71 5.487±0.39 1.589±0.90 49.990±1.09 2.837±1.71 18.485±3.52 6.381±2.88 0.968±0.32

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00020S CIL_00020S_0002 CGP 1:59684971-59879014
CIL_0000JN CIL_0000JN_0004 CGP 1:59763400-59985346

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001707 IMP mesoderm formation
GO:0001938 IEA positive regulation of endothelial cell proliferation
GO:0001946 IMP lymphangiogenesis
GO:0001974 IMP blood vessel remodeling
GO:0002063 IEA chondrocyte development
GO:0003085 IEA negative regulation of systemic arterial blood pressure
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0005024 IEA transforming growth factor beta-activated receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005615 IEA extracellular space
GO:0005737 IEA cytoplasm
GO:0005886 IEA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0005901 IEA caveola
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007178 IEA transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007420 IEA brain development
GO:0009267 IEA cellular response to starvation
GO:0009925 IEA basal plasma membrane
GO:0009952 IMP anterior/posterior pattern specification
GO:0009986 IDA cell surface
GO:0010595 IEA positive regulation of endothelial cell migration
GO:0010634 IEA positive regulation of epithelial cell migration
GO:0010862 IEA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014916 IMP regulation of lung blood pressure
GO:0016324 IEA apical plasma membrane
GO:0019838 IEA growth factor binding
GO:0023014 IEA signal transduction by phosphorylation
GO:0030308 IEA negative regulation of cell growth
GO:0030425 IEA dendrite
GO:0030501 IEA positive regulation of bone mineralization
GO:0030509 IMP BMP signaling pathway
GO:0030513 IEA positive regulation of BMP signaling pathway
GO:0042127 IEA regulation of cell proliferation
GO:0043025 IEA neuronal cell body
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0045906 IMP negative regulation of vasoconstriction
GO:0046872 IEA metal ion binding
GO:0048010 IMP vascular endothelial growth factor receptor signaling pathway
GO:0048286 IMP lung alveolus development
GO:0048842 IMP positive regulation of axon extension involved in axon guidance
GO:0060041 IEA retina development in camera-type eye
GO:0060173 IGI limb development
GO:0060836 IMP lymphatic endothelial cell differentiation
GO:0060840 IMP artery development
GO:0060841 IMP venous blood vessel development
GO:0061298 IMP retina vasculature development in camera-type eye
GO:1902731 IEA negative regulation of chondrocyte proliferation
GO:2000279 IEA negative regulation of DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000002334 bmpr2b-201 protein_coding Danio_rerio 0 592
ENSDART00000125961 bmpr2b-001 protein_coding Danio_rerio 0 592
ENST00000374574 BMPR2-002 protein_coding Homo_sapiens 0 2207
ENST00000374580 BMPR2-001 protein_coding Homo_sapiens 0 5485
ENST00000479069 BMPR2-003 processed_transcript Homo_sapiens 0 446

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