C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: mitogen-activated protein kinase kinase kinase 5
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000359015 MAP3K5-001 ENSG00000197442 9606 - 6:136557047-136792518 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000359015
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000359015 10.820±0.00 3.622±0.00 7.336±1.09 2.220±0.60 4.913±0.64 4.764±2.53 2.856±2.46 3.487±1.25 4.837±0.00 0.588±0.18 13.632±7.16 2.676±0.52 7.175±2.09

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 IDA MAPK cascade
GO:0000186 IDA activation of MAPKK activity
GO:0000187 IEA activation of MAPK activity
GO:0000287 IDA magnesium ion binding
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002931 IEA response to ischemia
GO:0004672 IDA:IEA protein kinase activity
GO:0004709 IDA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005783 IEA endoplasmic reticulum
GO:0005829 TAS cytosol
GO:0006468 IDA:IEA protein phosphorylation
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007254 IDA JNK cascade
GO:0007257 TAS activation of JUN kinase activity
GO:0008631 IDA intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008656 IDA cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010941 IEA regulation of cell death
GO:0016032 IEA viral process
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019901 IEA protein kinase binding
GO:0019903 IPI protein phosphatase binding
GO:0042803 IDA protein homodimerization activity
GO:0043065 IDA positive regulation of apoptotic process
GO:0043280 IDA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 IEA innate immune response
GO:0070301 IDA cellular response to hydrogen peroxide
GO:0097190 TAS apoptotic signaling pathway
GO:0097300 IEA programmed necrotic cell death
GO:1901216 IGI positive regulation of neuron death
GO:1902170 IEA cellular response to reactive nitrogen species
GO:1902911 IDA protein kinase complex

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000095806 Map3k5-001 protein_coding Mus_musculus 0 4817
ENSMUST00000120259 Map3k5-002 protein_coding Mus_musculus 0 4455
ENSMUST00000129437 Map3k5-003 protein_coding Mus_musculus 0 713
ENSDART00000006615 MAP3K15-201 protein_coding Danio_rerio 0 368
ENSDART00000143099 MAP3K15-001 protein_coding Danio_rerio 0 368
ENSMUST00000152533 Map3k5-004 protein_coding Mus_musculus 0 313
ENSMUST00000156369 Map3k5-006 retained_intron Mus_musculus 0 291

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