C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: tuberous sclerosis 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000097373 Tsc2-201 ENSMUSG00000002496 10090 - 17:24595937-24632629 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000097373
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000097373 23.552±0.14 22.088±4.72 16.968±1.94 20.934±5.27 19.367±8.21 21.382±0.40 16.737±5.70 19.888±3.43 7.895±2.97 29.708±7.11 26.646±9.20 5.725±2.13 5.874±1.69

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001666 IMP response to hypoxia
GO:0001843 IMP neural tube closure
GO:0005096 IBA GTPase activator activity
GO:0005515 IEA protein binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005829 IEA cytosol
GO:0005856 IEA cytoskeleton
GO:0005901 IEA caveola
GO:0006469 IMP negative regulation of protein kinase activity
GO:0006606 IMP protein import into nucleus
GO:0006953 IEA acute-phase response
GO:0007165 IEA signal transduction
GO:0007507 IMP heart development
GO:0008104 IDA protein localization
GO:0008285 IMP negative regulation of cell proliferation
GO:0014065 IMP phosphatidylinositol 3-kinase signaling
GO:0014067 IMP negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IEA membrane
GO:0019902 IEA phosphatase binding
GO:0030030 ISO cell projection organization
GO:0030100 IMP regulation of endocytosis
GO:0030178 IBA negative regulation of Wnt signaling pathway
GO:0030425 IEA dendrite
GO:0030426 IEA growth cone
GO:0032007 IMP negative regulation of TOR signaling
GO:0032320 IBA positive regulation of Ras GTPase activity
GO:0032869 IMP cellular response to insulin stimulus
GO:0033596 IBA TSC1-TSC2 complex
GO:0042803 IEA protein homodimerization activity
GO:0043005 IEA neuron projection
GO:0043025 IEA neuronal cell body
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043234 IEA protein complex
GO:0043407 IEA negative regulation of MAP kinase activity
GO:0043491 IGI protein kinase B signaling
GO:0044861 IMP protein transport into plasma membrane raft
GO:0045121 IEA membrane raft
GO:0045184 IEA establishment of protein localization
GO:0045792 ISO negative regulation of cell size
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046323 IMP glucose import
GO:0046626 IMP regulation of insulin receptor signaling pathway
GO:0046627 IBA negative regulation of insulin receptor signaling pathway
GO:0046982 IEA protein heterodimerization activity
GO:0048009 IGI insulin-like growth factor receptor signaling pathway
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0050918 IMP positive chemotaxis
GO:0051260 IEA protein homooligomerization
GO:0051291 IEA protein heterooligomerization
GO:0051726 IBA regulation of cell cycle
GO:0051898 IGI negative regulation of protein kinase B signaling
GO:0071889 IDA 14-3-3 protein binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000219476 TSC2-001 protein_coding Homo_sapiens 0 3181
ENST00000350773 TSC2-004 protein_coding Homo_sapiens 0 3155
ENST00000382538 TSC2-007 protein_coding Homo_sapiens 0 5046
ENST00000401874 TSC2-003 protein_coding Homo_sapiens 0 5245
ENST00000432909 TSC2-020 protein_coding Homo_sapiens 0 294
ENST00000439117 TSC2-002 nonsense_mediated_decay Homo_sapiens 0 3240
ENST00000439673 TSC2-017 protein_coding Homo_sapiens 0 4900
ENST00000461648 TSC2-008 retained_intron Homo_sapiens 0 363
ENST00000467949 TSC2-009 protein_coding Homo_sapiens 0 414
ENST00000490108 TSC2-011 retained_intron Homo_sapiens 0 449
ENST00000497886 TSC2-005 retained_intron Homo_sapiens 0 1493
ENST00000568366 TSC2-024 processed_transcript Homo_sapiens 0 453
ENST00000568454 TSC2-006 protein_coding Homo_sapiens 0 5225
ENST00000568692 TSC2-026 retained_intron Homo_sapiens 0 292

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