C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: tuberous sclerosis 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000382538 TSC2-007 ENSG00000103197 9606 + 16:2047980-2088700 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeKidneyLiverMusclePlacentaTestisENST00000382538
Transcript ID Adipose Kidney Liver Muscle Placenta Testis
ENST00000382538 4.578±0.00 7.725±0.00 3.279±0.00 11.021±0.00 5.511±0.17 15.921±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00029D CIL_00029D_0002 CGP 16:2047465-2135898

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001843 ISS neural tube closure
GO:0005096 IDA:IEA GTPase activator activity
GO:0005488 IEA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0005829 IDA cytosol
GO:0006469 ISS negative regulation of protein kinase activity
GO:0006606 ISS protein import into nucleus
GO:0006897 TAS endocytosis
GO:0007050 TAS cell cycle arrest
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007507 ISS heart development
GO:0008104 ISS protein localization
GO:0008285 ISS negative regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0014067 ISS negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IDA membrane
GO:0016192 TAS vesicle-mediated transport
GO:0019902 IDA phosphatase binding
GO:0030100 ISS regulation of endocytosis
GO:0030178 IBA negative regulation of Wnt signaling pathway
GO:0032007 IBA negative regulation of TOR signaling
GO:0032320 IBA positive regulation of Ras GTPase activity
GO:0033596 IDA TSC1-TSC2 complex
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042803 IPI protein homodimerization activity
GO:0043491 ISS protein kinase B signaling
GO:0043547 IEA positive regulation of GTPase activity
GO:0045087 TAS innate immune response
GO:0046626 ISS regulation of insulin receptor signaling pathway
GO:0046627 IBA negative regulation of insulin receptor signaling pathway
GO:0048009 ISS insulin-like growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050918 ISS positive chemotaxis
GO:0051056 IEA regulation of small GTPase mediated signal transduction
GO:0051726 IBA regulation of cell cycle
GO:0051898 ISS negative regulation of protein kinase B signaling

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000097373 Tsc2-201 protein_coding Mus_musculus 0 5046

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