C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: a disintegrin and metallopeptidase domain 17
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000101551 Adam17-002 ENSMUSG00000052593 10090 - 12:21323509-21373593 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; ColonENSMUST00000101551
Transcript ID Colon
ENSMUST00000101551 3.392±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00057M CIL_00057M_0002 CGP 12:21286297-21323605
CIL_0007AU CIL_0007AU_0003 CGP 12:21316392-21373632
CIL_0001MI CIL_0001MI_0002 CGP 12:21323509-21417637

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0004222 IEA metalloendopeptidase activity
GO:0005112 IEA Notch binding
GO:0005138 IEA interleukin-6 receptor binding
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005887 IEA integral component of plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005925 IEA focal adhesion
GO:0006508 IEA proteolysis
GO:0006509 IEA membrane protein ectodomain proteolysis
GO:0007155 IEA cell adhesion
GO:0007173 IEA epidermal growth factor receptor signaling pathway
GO:0007220 IEA Notch receptor processing
GO:0008237 IEA metallopeptidase activity
GO:0008270 IEA zinc ion binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0009986 IEA cell surface
GO:0010820 IEA positive regulation of T cell chemotaxis
GO:0015629 IEA actin cytoskeleton
GO:0016020 IEA membrane
GO:0016324 IEA apical plasma membrane
GO:0030165 IEA PDZ domain binding
GO:0030307 IEA positive regulation of cell growth
GO:0030335 IEA positive regulation of cell migration
GO:0030512 IEA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031659 IEA positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0032496 IEA response to lipopolysaccharide
GO:0032587 IEA ruffle membrane
GO:0032717 IEA negative regulation of interleukin-8 production
GO:0032722 IEA positive regulation of chemokine production
GO:0033627 IEA cell adhesion mediated by integrin
GO:0035313 IEA wound healing, spreading of epidermal cells
GO:0035625 IEA epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0045121 IEA membrane raft
GO:0045741 IEA positive regulation of epidermal growth factor-activated receptor activity
GO:0051088 IEA PMA-inducible membrane protein ectodomain proteolysis
GO:0055099 IEA response to high density lipoprotein particle

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000135391 adam17b-201 protein_coding Danio_rerio 4e-38 165
ENSDART00000153339 adam17b-001 protein_coding Danio_rerio 4e-38 165
ENST00000310823 ADAM17-001 protein_coding Homo_sapiens 0 2128
ENST00000470914 IAH1-001 protein_coding Homo_sapiens 2.00386e-43 182
ENST00000478059 ADAM17-002 retained_intron Homo_sapiens 0 695
ENST00000484826 IAH1-014 retained_intron Homo_sapiens 0.00000002 64
ENST00000497134 ADAM17-003 protein_coding Homo_sapiens 0 826
ENST00000497473 IAH1-003 protein_coding Homo_sapiens 9.94922e-44 182
ENST00000618923 ADAM17-201 protein_coding Homo_sapiens 0 826

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