C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: 3-phosphoinositide dependent protein kinase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000102927 Pdpk1-001 ENSMUSG00000024122 10090 - 17:24073680-24141595 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000102927
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000102927 8.090±1.22 5.636±1.01 8.201±1.34 12.783±9.73 5.798±1.20 6.822±1.35 4.857±0.58 6.605±0.55 6.178±3.34 6.677±2.85 3.711±1.21 5.927±2.87 6.453±2.83 7.495±0.09

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005ER CIL_0005ER_0002 CGP 17:24047734-24150924

Gene Ontology

GO IDEvidence TypeGO Description
GO:0003323 IMP type B pancreatic cell development
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004676 IDA 3-phosphoinositide-dependent protein kinase activity
GO:0005158 IEA insulin receptor binding
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0005886 IEA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006469 IEA negative regulation of protein kinase activity
GO:0006972 IDA hyperosmotic response
GO:0007165 TAS signal transduction
GO:0007173 IEA epidermal growth factor receptor signaling pathway
GO:0010518 IEA positive regulation of phospholipase activity
GO:0010594 IMP regulation of endothelial cell migration
GO:0010667 IMP negative regulation of cardiac muscle cell apoptotic process
GO:0016004 IEA phospholipase activator activity
GO:0016023 IDA cytoplasmic membrane-bounded vesicle
GO:0016301 IEA kinase activity
GO:0016477 IEA cell migration
GO:0018107 IEA peptidyl-threonine phosphorylation
GO:0019722 IEA calcium-mediated signaling
GO:0019901 IEA protein kinase binding
GO:0030054 IEA cell junction
GO:0030512 IEA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032148 IEA activation of protein kinase B activity
GO:0032869 IEA cellular response to insulin stimulus
GO:0034122 IMP negative regulation of toll-like receptor signaling pathway
GO:0035556 IEA intracellular signal transduction
GO:0042995 IEA cell projection
GO:0043122 IEA regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043274 IEA phospholipase binding
GO:0043304 IMP regulation of mast cell degranulation
GO:0048041 IEA focal adhesion assembly
GO:0051281 IEA positive regulation of release of sequestered calcium ion into cytosol
GO:0071364 IEA cellular response to epidermal growth factor stimulus
GO:0090004 IEA positive regulation of establishment of protein localization to plasma membrane
GO:0097191 IEA extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000003789 pdpk1b-001 protein_coding Danio_rerio 4e-30 139
ENST00000268673 PDPK1-002 protein_coding Homo_sapiens 0 1467
ENST00000342085 PDPK1-001 protein_coding Homo_sapiens 0 2505
ENST00000382326 PDPK2P-002 processed_transcript Homo_sapiens 0 1282
ENST00000389224 PDPK1-003 protein_coding Homo_sapiens 0 2132
ENST00000441549 PDPK1-013 protein_coding Homo_sapiens 0 1722
ENST00000460496 PDPK1-009 processed_transcript Homo_sapiens 0 385
ENST00000461815 PDPK1-008 protein_coding Homo_sapiens 0 503
ENST00000462923 PDPK1-016 processed_transcript Homo_sapiens 0 207
ENST00000464702 PDPK1-010 processed_transcript Homo_sapiens 0 377
ENST00000471311 PDPK1-011 processed_transcript Homo_sapiens 0 302
ENST00000474706 PDPK1-006 nonsense_mediated_decay Homo_sapiens 0 263
ENST00000491073 PDPK1-005 retained_intron Homo_sapiens 0 1277
ENST00000492021 PDPK1-007 nonsense_mediated_decay Homo_sapiens 0 239
ENST00000562415 PDPK2P-001 transcribed_unprocessed_pseudogene Homo_sapiens 0 1197
ENST00000566659 PDPK1-015 protein_coding Homo_sapiens 0 383
ENST00000570136 PDPK1-014 retained_intron Homo_sapiens 0 436
ENST00000571865 PDPK2P-003 processed_transcript Homo_sapiens 0 219

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