C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: parkinson protein 7
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000493678 PARK7-001 ENSG00000116288 9606 + 1:7961692-7985505 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastColonKidneyLungMuscleENST00000493678
Transcript ID Bladder Brain Breast Colon Kidney Lung Muscle
ENST00000493678 5.984±0.00 16.455±0.00 4.605±0.00 7.173±0.00 22.058±0.00 4.386±0.00 13.511±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007VW CIL_0007VW_0001 VISTA 1:7770379-8371827

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000785 IDA chromatin
GO:0001933 IGI negative regulation of protein phosphorylation
GO:0001963 IEA synaptic transmission, dopaminergic
GO:0003713 IGI transcription coactivator activity
GO:0003729 IDA mRNA binding
GO:0005102 IPI receptor binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005747 IDA mitochondrial respiratory chain complex I
GO:0005758 IEA mitochondrial intermembrane space
GO:0005759 IEA mitochondrial matrix
GO:0005829 IDA cytosol
GO:0005886 IEA plasma membrane
GO:0006469 IGI negative regulation of protein kinase activity
GO:0006508 IEA proteolysis
GO:0006914 IEA autophagy
GO:0006954 IEA inflammatory response
GO:0007005 ISS mitochondrion organization
GO:0007265 TAS Ras protein signal transduction
GO:0007338 IEA single fertilization
GO:0008134 IPI transcription factor binding
GO:0008233 IDA peptidase activity
GO:0008344 IEA adult locomotory behavior
GO:0010628 TAS positive regulation of gene expression
GO:0010629 IDA negative regulation of gene expression
GO:0016532 IDA superoxide dismutase copper chaperone activity
GO:0016605 IDA PML body
GO:0016684 IDA oxidoreductase activity, acting on peroxide as acceptor
GO:0018323 IEA enzyme active site formation via L-cysteine sulfinic acid
GO:0019172 IDA glyoxalase III activity
GO:0019243 IDA methylglyoxal catabolic process to D-lactate
GO:0019249 IDA lactate biosynthetic process
GO:0019899 IPI enzyme binding
GO:0019955 IPI cytokine binding
GO:0030424 ISS axon
GO:0031397 IDA negative regulation of protein ubiquitination
GO:0032091 IDA negative regulation of protein binding
GO:0032148 IC activation of protein kinase B activity
GO:0032435 IDA negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032757 IDA positive regulation of interleukin-8 production
GO:0033138 IMP positive regulation of peptidyl-serine phosphorylation
GO:0033234 IDA negative regulation of protein sumoylation
GO:0034599 IDA cellular response to oxidative stress
GO:0034614 IEA cellular response to reactive oxygen species
GO:0036470 IDA tyrosine 3-monooxygenase activator activity
GO:0036471 IDA cellular response to glyoxal
GO:0036478 IDA L-dopa decarboxylase activator activity
GO:0042177 IEA negative regulation of protein catabolic process
GO:0042542 IEA response to hydrogen peroxide
GO:0042743 IDA hydrogen peroxide metabolic process
GO:0042802 IPI identical protein binding
GO:0042803 IDA protein homodimerization activity
GO:0043005 IEA neuron projection
GO:0043066 IDA negative regulation of apoptotic process
GO:0043523 IDA regulation of neuron apoptotic process
GO:0043524 IDA negative regulation of neuron apoptotic process
GO:0044297 IEA cell body
GO:0044388 IPI small protein activating enzyme binding
GO:0044390 IPI small protein conjugating enzyme binding
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046295 IDA glycolate biosynthetic process
GO:0046826 IGI negative regulation of protein export from nucleus
GO:0050681 IPI androgen receptor binding
GO:0050727 ISS regulation of inflammatory response
GO:0050821 IMP protein stabilization
GO:0051091 IMP positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051444 IDA negative regulation of ubiquitin-protein transferase activity
GO:0051583 IEA dopamine uptake involved in synaptic transmission
GO:0051881 IMP regulation of mitochondrial membrane potential
GO:0051897 IC positive regulation of protein kinase B signaling
GO:0051899 IEA membrane depolarization
GO:0051920 IEA peroxiredoxin activity
GO:0055114 IEA oxidation-reduction process
GO:0060081 IEA membrane hyperpolarization
GO:0060548 IDA negative regulation of cell death
GO:0060765 IDA regulation of androgen receptor signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:0070301 IDA cellular response to hydrogen peroxide
GO:0070491 IPI repressing transcription factor binding
GO:0090073 IDA positive regulation of protein homodimerization activity
GO:0097110 IPI scaffold protein binding
GO:1900182 IDA positive regulation of protein localization to nucleus
GO:1901215 IDA negative regulation of neuron death
GO:1901671 IDA positive regulation of superoxide dismutase activity
GO:1901984 IDA negative regulation of protein acetylation
GO:1902903 TAS regulation of fibril organization
GO:1902958 IMP positive regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903073 IC negative regulation of death-inducing signaling complex assembly
GO:1903094 IDA negative regulation of protein K48-linked deubiquitination
GO:1903122 IMP negative regulation of TRAIL-activated apoptotic signaling pathway
GO:1903135 IDA cupric ion binding
GO:1903136 IDA cuprous ion binding
GO:1903168 IDA positive regulation of pyrroline-5-carboxylate reductase activity
GO:1903178 IDA positive regulation of tyrosine 3-monooxygenase activity
GO:1903181 IC positive regulation of dopamine biosynthetic process
GO:1903190 IDA glyoxal catabolic process
GO:1903197 IMP positive regulation of L-dopa biosynthetic process
GO:1903200 IDA positive regulation of L-dopa decarboxylase activity
GO:1903202 IDA negative regulation of oxidative stress-induced cell death
GO:1903204 IEA negative regulation of oxidative stress-induced neuron death
GO:1903206 IMP negative regulation of hydrogen peroxide-induced cell death
GO:1903208 IDA negative regulation of hydrogen peroxide-induced neuron death
GO:1903377 IDA negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1990381 IPI ubiquitin-specific protease binding
GO:1990422 IDA glyoxalase (glycolic acid-forming) activity
GO:2000157 IDA negative regulation of ubiquitin-specific protease activity
GO:2000277 IEA positive regulation of oxidative phosphorylation uncoupler activity
GO:2000679 IMP positive regulation of transcription regulatory region DNA binding
GO:2000825 IMP positive regulation of androgen receptor activity
GO:2001237 IMP negative regulation of extrinsic apoptotic signaling pathway
GO:2001268 IMP negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000105673 Park7-002 protein_coding Mus_musculus 0 571
ENSMUST00000105674 Park7-003 protein_coding Mus_musculus 0 571
ENSMUST00000105675 Park7-009 protein_coding Mus_musculus 0 571
ENSMUST00000030805 Park7-001 protein_coding Mus_musculus 0 571
ENSMUST00000105676 Park7-004 protein_coding Mus_musculus 0 547
ENSMUST00000128075 Park7-005 protein_coding Mus_musculus 0 470
ENSMUST00000148626 Park7-007 retained_intron Mus_musculus 0 372
ENSMUST00000146184 Park7-010 protein_coding Mus_musculus 0 305
ENSMUST00000134751 Park7-006 protein_coding Mus_musculus 0 305

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