C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: phosphodiesterase 4D, cAMP-specific
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000340635 PDE4D-001 ENSG00000113448 9606 - 5:58969038-59893798 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainBreastKidneyLiverOvaryENST00000340635
Transcript ID Brain Breast Kidney Liver Ovary
ENST00000340635 2.445±0.00 0.364±0.00 1.373±0.00 4.615±0.00 0.086±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002027 ISS regulation of heart rate
GO:0004112 IEA cyclic-nucleotide phosphodiesterase activity
GO:0004114 IEA:NAS 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 IDA 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515 IPI protein binding
GO:0005794 IEA Golgi apparatus
GO:0005813 IEA centrosome
GO:0005829 IDA cytosol
GO:0005856 IEA cytoskeleton
GO:0005886 IEA plasma membrane
GO:0005891 ISS voltage-gated calcium channel complex
GO:0006198 IEA cAMP catabolic process
GO:0006939 IEA smooth muscle contraction
GO:0007165 IEA signal transduction
GO:0007568 IEA aging
GO:0007613 IEA memory
GO:0008144 IPI drug binding
GO:0008277 IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0010469 ISS regulation of receptor activity
GO:0010738 IEA regulation of protein kinase A signaling
GO:0010880 ISS regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014911 IEA positive regulation of smooth muscle cell migration
GO:0016020 IDA membrane
GO:0017124 IEA SH3 domain binding
GO:0019899 ISS enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0019933 NAS cAMP-mediated signaling
GO:0030016 IEA myofibril
GO:0030324 IEA lung development
GO:0030552 IDA cAMP binding
GO:0030593 IEA neutrophil chemotaxis
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031698 ISS beta-2 adrenergic receptor binding
GO:0032729 IMP positive regulation of interferon-gamma production
GO:0032743 IMP positive regulation of interleukin-2 production
GO:0032754 IMP positive regulation of interleukin-5 production
GO:0033137 ISS negative regulation of peptidyl-serine phosphorylation
GO:0034704 IDA calcium channel complex
GO:0035264 IEA multicellular organism growth
GO:0043623 IEA cellular protein complex assembly
GO:0044325 ISS ion channel binding
GO:0045822 ISS negative regulation of heart contraction
GO:0046872 IEA metal ion binding
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050852 IMP T cell receptor signaling pathway
GO:0050900 IEA leukocyte migration
GO:0051117 IPI ATPase binding
GO:0060314 ISS regulation of ryanodine-sensitive calcium-release channel activity
GO:0061028 ISS establishment of endothelial barrier
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071320 IDA cellular response to cAMP
GO:0071872 IDA cellular response to epinephrine stimulus
GO:0071875 ISS adrenergic receptor signaling pathway
GO:0086004 ISS regulation of cardiac muscle cell contraction
GO:0086024 IC adrenergic receptor signaling pathway involved in positive regulation of heart rate
GO:0097110 IPI scaffold protein binding
GO:1901844 IC regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901898 ISS negative regulation of relaxation of cardiac muscle

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000120671 Pde4d-003 protein_coding Mus_musculus 0 3147
ENSMUST00000122041 Pde4d-001 protein_coding Mus_musculus 0 2625
ENSMUST00000074103 Pde4d-009 protein_coding Mus_musculus 0 2623
ENSMUST00000135275 Pde4d-008 protein_coding Mus_musculus 0 2588
ENSMUST00000119507 Pde4d-007 protein_coding Mus_musculus 0 2588
ENSMUST00000153234 Pde4d-005 protein_coding Mus_musculus 0 2588
ENSMUST00000177907 Pde4d-201 protein_coding Mus_musculus 0 2584
ENSMUST00000079975 Pde4d-019 protein_coding Mus_musculus 0 2584
ENSMUST00000120664 Pde4d-011 protein_coding Mus_musculus 0 2470
ENSMUST00000119672 Pde4d-012 nonsense_mediated_decay Mus_musculus 0 2069
ENSMUST00000117420 Pde4d-014 protein_coding Mus_musculus 0 1869
ENSMUST00000117879 Pde4d-013 protein_coding Mus_musculus 0 1864
ENSDART00000002096 pde4ca-201 protein_coding Danio_rerio 0 780
ENSDART00000141030 pde4ca-001 protein_coding Danio_rerio 0 780
ENSMUST00000155459 Pde4d-018 protein_coding Mus_musculus 0 693
ENSMUST00000151429 Pde4d-017 retained_intron Mus_musculus 0 656
ENSMUST00000138938 Pde4d-004 retained_intron Mus_musculus 0 599
ENSMUST00000129374 Pde4d-006 processed_transcript Mus_musculus 0 599
ENSMUST00000134973 Pde4d-010 retained_intron Mus_musculus 0 521
ENSMUST00000120746 Ncald-002 protein_coding Mus_musculus 0.0002 53
ENSMUST00000119730 Ncald-003 protein_coding Mus_musculus 0.0002 53
ENSMUST00000132423 Ncald-011 processed_transcript Mus_musculus 0.00004 53

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