C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: PTK2 protein tyrosine kinase 2 beta
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000178730 Ptk2b-201 ENSMUSG00000059456 10090 - 14:66153258-66213552 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastLiverMuscleOvaryPlacentaTestisENSMUST00000178730
Transcript ID Bladder Brain Breast Liver Muscle Ovary Placenta Testis
ENSMUST00000178730 11.331±0.00 91.754±0.00 2.649±0.00 1.515±0.00 0.207±0.12 19.545±6.35 4.624±3.60 2.841±1.21

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000OS CIL_0000OS_0003 CGP 14:66140960-66281052

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001954 ISS positive regulation of cell-matrix adhesion
GO:0002040 IMP sprouting angiogenesis
GO:0002315 IMP marginal zone B cell differentiation
GO:0004672 IDA protein kinase activity
GO:0004683 ISS calmodulin-dependent protein kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0004972 ISS N-methyl-D-aspartate selective glutamate receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0005925 IEA focal adhesion
GO:0006468 IDA protein phosphorylation
GO:0006968 ISS cellular defense response
GO:0007166 ISS cell surface receptor signaling pathway
GO:0007172 IEA signal complex assembly
GO:0007229 ISS integrin-mediated signaling pathway
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0008360 IMP regulation of cell shape
GO:0010595 IMP positive regulation of endothelial cell migration
GO:0010752 IMP regulation of cGMP-mediated signaling
GO:0010758 IMP regulation of macrophage chemotaxis
GO:0014069 ISS postsynaptic density
GO:0017146 ISS N-methyl-D-aspartate selective glutamate receptor complex
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0030027 ISS lamellipodium
GO:0030155 ISS regulation of cell adhesion
GO:0030425 ISS dendrite
GO:0030426 ISS growth cone
GO:0030502 IMP negative regulation of bone mineralization
GO:0030826 IMP regulation of cGMP biosynthetic process
GO:0030838 ISS positive regulation of actin filament polymerization
GO:0032960 IMP regulation of inositol trisphosphate biosynthetic process
GO:0035235 ISS ionotropic glutamate receptor signaling pathway
GO:0038083 ISS peptidyl-tyrosine autophosphorylation
GO:0043025 ISS neuronal cell body
GO:0043066 IMP negative regulation of apoptotic process
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0043552 IMP positive regulation of phosphatidylinositol 3-kinase activity
GO:0044297 ISS cell body
GO:0045428 IMP regulation of nitric oxide biosynthetic process
GO:0045453 IMP bone resorption
GO:0045766 IMP positive regulation of angiogenesis
GO:0045860 ISS positive regulation of protein kinase activity
GO:0046330 ISS positive regulation of JNK cascade
GO:0048010 IMP vascular endothelial growth factor receptor signaling pathway
GO:0050848 IMP regulation of calcium-mediated signaling
GO:0051000 IMP positive regulation of nitric-oxide synthase activity
GO:0051279 IMP regulation of release of sequestered calcium ion into cytosol
GO:0051968 ISS positive regulation of synaptic transmission, glutamatergic
GO:0060291 ISS long-term synaptic potentiation
GO:0070098 IMP chemokine-mediated signaling pathway
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0097440 ISS apical dendrite
GO:2000060 IMP positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000114 IMP regulation of establishment of cell polarity
GO:2000249 IMP regulation of actin cytoskeleton reorganization
GO:2000310 ISS regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000463 ISS positive regulation of excitatory postsynaptic membrane potential
GO:2000538 IMP positive regulation of B cell chemotaxis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000346049 PTK2B-001 protein_coding Homo_sapiens 0 3975
ENST00000397497 PTK2B-003 protein_coding Homo_sapiens 0 1797
ENST00000397501 PTK2B-009 protein_coding Homo_sapiens 0 3975
ENST00000412793 PTK2B-007 protein_coding Homo_sapiens 0 861
ENST00000420218 PTK2B-201 protein_coding Homo_sapiens 0 2885
ENST00000461615 PTK2B-006 retained_intron Homo_sapiens 0 320
ENST00000517339 PTK2B-002 protein_coding Homo_sapiens 0 2885
ENST00000519512 PTK2B-011 protein_coding Homo_sapiens 0 488
ENST00000521000 PTK2B-016 retained_intron Homo_sapiens 0 444
ENST00000521164 PTK2B-014 protein_coding Homo_sapiens 0 433
ENST00000522245 PTK2B-017 retained_intron Homo_sapiens 0 322
ENST00000522517 PTK2B-015 protein_coding Homo_sapiens 0 767

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