C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: dishevelled segment polarity protein 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000005340 DVL2-001 ENSG00000004975 9606 - 17:7225341-7234545 protein_coding

Homo sapiens EnsemblGRCh38

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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastColonKidneyLiverMuscleOvaryPlacentaTestisENST00000005340
Transcript ID Adipose Brain Breast Colon Kidney Liver Muscle Ovary Placenta Testis
ENST00000005340 8.578±0.00 2.411±1.91 8.539±0.00 8.753±0.00 3.020±2.85 1.358±0.74 4.591±0.00 17.889±7.63 6.576±2.65 8.971±1.55

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001843 ISS neural tube closure
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0003007 IBA heart morphogenesis
GO:0003151 ISS outflow tract morphogenesis
GO:0005109 IPI frizzled binding
GO:0005515 IPI:IEA protein binding
GO:0005634 ISS nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IBA plasma membrane
GO:0005938 IBA cell cortex
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007379 ISS segment specification
GO:0007507 ISS heart development
GO:0016055 IGI Wnt signaling pathway
GO:0019904 IEA protein domain specific binding
GO:0021535 IBA cell migration in hindbrain
GO:0022007 IEA convergent extension involved in neural plate elongation
GO:0030136 IBA clathrin-coated vesicle
GO:0031410 IDA cytoplasmic vesicle
GO:0034613 IEA cellular protein localization
GO:0035282 IEA segmentation
GO:0035329 TAS hippo signaling
GO:0035556 IEA intracellular signal transduction
GO:0035567 IMP non-canonical Wnt signaling pathway
GO:0042802 IPI identical protein binding
GO:0043507 IDA positive regulation of JUN kinase activity
GO:0043621 IEA protein self-association
GO:0044340 IDA canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0045177 IBA apical part of cell
GO:0045334 TAS clathrin-coated endocytic vesicle
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060026 IBA convergent extension
GO:0060029 IEA convergent extension involved in organogenesis
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060071 IDA Wnt signaling pathway, planar cell polarity pathway
GO:0061098 IEA positive regulation of protein tyrosine kinase activity
GO:0090103 IBA cochlea morphogenesis
GO:0090179 IBA planar cell polarity pathway involved in neural tube closure
GO:0090263 IEA positive regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000190940 Dvl2-201 protein_coding Mus_musculus 0 2950
ENSMUST00000102575 Dvl2-006 nonsense_mediated_decay Mus_musculus 0 2950
ENSMUST00000019362 Dvl2-001 protein_coding Mus_musculus 0 2942
ENSMUST00000130820 Dvl2-004 retained_intron Mus_musculus 0 1273
ENSMUST00000171572 Dvl3-003 protein_coding Mus_musculus 0 617
ENSMUST00000003318 Dvl3-001 protein_coding Mus_musculus 0 617
ENSMUST00000135422 Dvl2-002 retained_intron Mus_musculus 0 560
ENSMUST00000171774 Dvl3-004 protein_coding Mus_musculus 0 431
ENSDART00000007181 DVL3 (1 of 2)-201 protein_coding Danio_rerio 0 230
ENSDART00000035755 DVL1 (1 of 3)-201 protein_coding Danio_rerio 0 224
ENSDART00000143583 DVL1 (1 of 3)-001 protein_coding Danio_rerio 0 224
ENSDART00000150174 DVL1 (3 of 3)-001 protein_coding Danio_rerio 2e-18 99

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