C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: interleukin-1 receptor-associated kinase 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000256458 IRAK2-001 ENSG00000134070 9606 + 3:10164865-10243743 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000256458
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000256458 7.531±0.00 2.020±0.00 0.763±0.00 1.371±0.95 1.129±0.38 0.989±0.77 0.456±0.22 1.470±0.00 1.493±0.00 10.694±9.94 6.525±6.01 2.156±1.29 0.664±0.16 0.631±0.55

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00061P CIL_00061P_0001 CGP 3:10141008-10243743
CIL_00061O CIL_00061O_0001 CGP 3:10164865-10281218

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000187 TAS activation of MAPK activity
GO:0001959 IMP regulation of cytokine-mediated signaling pathway
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0006954 TAS inflammatory response
GO:0007165 IEA signal transduction
GO:0007249 TAS I-kappaB kinase/NF-kappaB signaling
GO:0007254 TAS JNK cascade
GO:0010008 TAS endosome membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0031663 IEA lipopolysaccharide-mediated signaling pathway
GO:0032088 IMP negative regulation of NF-kappaB transcription factor activity
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042803 IPI protein homodimerization activity
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087 TAS innate immune response
GO:0046982 IPI protein heterodimerization activity
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0051403 TAS stress-activated MAPK cascade
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498 IMP interleukin-1-mediated signaling pathway
GO:0070555 IMP response to interleukin-1

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000059286 Irak2-001 protein_coding Mus_musculus 0 1107
ENSMUST00000089022 Irak2-004 protein_coding Mus_musculus 0 366
ENSMUST00000089023 Irak2-002 protein_coding Mus_musculus 5e-31 141

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