C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: receptor (TNFRSF)-interacting serine-threonine kinase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000259808 RIPK1-005 ENSG00000137275 9606 + 6:3068424-3115185 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000259808
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000259808 9.222±0.00 7.025±0.00 2.134±0.00 0.915±0.66 4.082±0.96 4.109±0.02 1.333±0.59 5.120±1.78 2.915±0.11 1.954±0.89 0.178±0.00 4.566±2.31 3.126±0.45 2.456±0.92

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00081I CIL_00081I_0001 VISTA 6:2946622-3549686
CIL_00038F CIL_00038F_0001 CGP 6:2987987-3115187
CIL_000823 CIL_000823_0001 VISTA 6:3049163-3652023
CIL_00038E CIL_00038E_0001 CGP 6:3063991-3153578

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005123 IPI death receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005739 IDA mitochondrion
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0006915 IMP apoptotic process
GO:0006919 TAS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 IEA signal transduction
GO:0007257 TAS activation of JUN kinase activity
GO:0010942 IEA positive regulation of cell death
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0031264 IDA death-inducing signaling complex
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032403 IDA protein complex binding
GO:0032481 TAS positive regulation of type I interferon production
GO:0032757 IDA positive regulation of interleukin-8 production
GO:0032760 IDA positive regulation of tumor necrosis factor production
GO:0033209 IC tumor necrosis factor-mediated signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034612 IMP response to tumor necrosis factor
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0036289 IDA peptidyl-serine autophosphorylation
GO:0042327 IEA positive regulation of phosphorylation
GO:0042802 IPI identical protein binding
GO:0043065 IDA positive regulation of apoptotic process
GO:0043068 IMP positive regulation of programmed cell death
GO:0043123 IEP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 IMP negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043234 IEA protein complex
GO:0043235 IDA receptor complex
GO:0043410 IEA positive regulation of MAPK cascade
GO:0044257 IDA cellular protein catabolic process
GO:0045087 TAS innate immune response
GO:0045121 IEA membrane raft
GO:0045651 IMP positive regulation of macrophage differentiation
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IDA positive regulation of JNK cascade
GO:0046777 IDA protein autophosphorylation
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0051260 IDA protein homooligomerization
GO:0051291 IMP protein heterooligomerization
GO:0051347 IEA positive regulation of transferase activity
GO:0060545 IMP positive regulation of necroptotic process
GO:0070231 ISS T cell apoptotic process
GO:0070266 IMP necroptotic process
GO:0070513 IPI death domain binding
GO:0070926 IMP regulation of ATP:ADP antiporter activity
GO:0071356 IDA cellular response to tumor necrosis factor
GO:0071363 IEA cellular response to growth factor stimulus
GO:0097190 TAS apoptotic signaling pathway
GO:0097191 IMP extrinsic apoptotic signaling pathway
GO:0097342 IDA ripoptosome
GO:0097343 IMP ripoptosome assembly
GO:0097527 ISS necroptotic signaling pathway
GO:1901026 IEA ripoptosome assembly involved in necroptotic process
GO:1990000 IMP amyloid fibril formation
GO:2000377 IEA regulation of reactive oxygen species metabolic process
GO:2000379 TAS positive regulation of reactive oxygen species metabolic process
GO:2001237 IMP negative regulation of extrinsic apoptotic signaling pathway
GO:2001238 IMP positive regulation of extrinsic apoptotic signaling pathway
GO:2001239 TAS regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240 IEA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000167374 Ripk1-002 protein_coding Mus_musculus 0 1343
ENSMUST00000021844 Ripk1-001 protein_coding Mus_musculus 0 1343
ENSMUST00000171137 Ripk1-004 protein_coding Mus_musculus 0 894
ENSMUST00000163418 Ripk1-003 retained_intron Mus_musculus 0 449

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