C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: peroxisome proliferator-activated receptor alpha
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000262735 PPARA-201 ENSG00000186951 9606 + 22:46150596-46243756 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262735
Transcript ID Adipose Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262735 2.604±0.00 1.764±0.00 1.601±0.00 1.715±0.25 5.483±4.24 8.693±0.00 11.403±0.00 1.028±0.00 4.669±0.00 0.935±0.24 0.503±0.15 1.562±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001Q1 CIL_0001Q1_0001 CGP 22:46150521-46250679

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001103 IPI RNA polymerase II repressing transcription factor binding
GO:0003677 TAS DNA binding
GO:0003700 ISS:IEA sequence-specific DNA binding transcription factor activity
GO:0003707 IDA:IEA steroid hormone receptor activity
GO:0004879 IDA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 TAS:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006629 TAS lipid metabolic process
GO:0008144 IDA drug binding
GO:0008270 IEA zinc ion binding
GO:0008289 IDA lipid binding
GO:0010467 TAS gene expression
GO:0010745 IC negative regulation of macrophage derived foam cell differentiation
GO:0010871 IDA negative regulation of receptor biosynthetic process
GO:0010887 IDA negative regulation of cholesterol storage
GO:0010891 IDA negative regulation of sequestering of triglyceride
GO:0015908 TAS fatty acid transport
GO:0030522 IEA intracellular receptor signaling pathway
GO:0031624 IPI ubiquitin conjugating enzyme binding
GO:0032000 TAS positive regulation of fatty acid beta-oxidation
GO:0032099 ISS negative regulation of appetite
GO:0032922 ISS circadian regulation of gene expression
GO:0042752 ISS regulation of circadian rhythm
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 ISS:IEA sequence-specific DNA binding
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045820 IC negative regulation of glycolytic process
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046321 ISS positive regulation of fatty acid oxidation
GO:0072363 IDA regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter
GO:0072366 IDA regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369 IDA regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000109423 Ppara-002 protein_coding Mus_musculus 0 1482
ENSMUST00000057979 Ppara-003 protein_coding Mus_musculus 0 1474
ENSMUST00000109422 Ppara-001 protein_coding Mus_musculus 0 1474
ENSDART00000123458 pparda-201 protein_coding Danio_rerio 0 329
ENSDART00000149743 pparda-001 protein_coding Danio_rerio 0 329
ENSMUST00000038014 Dnajc16-001 protein_coding Mus_musculus 0.00000000004 77

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