C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: insulin-degrading enzyme
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000265986 IDE-001 ENSG00000119912 9606 - 10:92451684-92574076 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265986
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265986 3.230±0.00 2.709±0.00 1.291±0.00 2.405±0.00 2.897±0.00 1.842±0.00 2.623±0.99 2.274±0.06 2.722±1.25 2.951±0.94 4.106±0.00 2.053±0.74 2.774±0.94 1.883±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00018P CIL_00018P_0001 CGP 10:92291163-92574076
CIL_00018U CIL_00018U_0001 CGP 10:92451684-92655395

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001540 IEA beta-amyloid binding
GO:0001948 IPI glycoprotein binding
GO:0003824 IEA catalytic activity
GO:0004222 IDA metalloendopeptidase activity
GO:0005102 IPI receptor binding
GO:0005515 IPI protein binding
GO:0005524 IDA ATP binding
GO:0005615 IDA extracellular space
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005777 IDA peroxisome
GO:0005782 IEA peroxisomal matrix
GO:0005829 IDA cytosol
GO:0005886 IEA plasma membrane
GO:0006200 IEA ATP catabolic process
GO:0006508 IDA proteolysis
GO:0008270 IDA zinc ion binding
GO:0008286 NAS insulin receptor signaling pathway
GO:0008340 IDA determination of adult lifespan
GO:0009986 IDA cell surface
GO:0010815 IDA bradykinin catabolic process
GO:0010992 IDA ubiquitin homeostasis
GO:0016032 IEA viral process
GO:0016887 IEA ATPase activity
GO:0017046 IEA peptide hormone binding
GO:0031597 IEA cytosolic proteasome complex
GO:0031626 IEA beta-endorphin binding
GO:0032461 IDA positive regulation of protein oligomerization
GO:0042277 IPI peptide binding
GO:0042447 IEA hormone catabolic process
GO:0042803 IPI protein homodimerization activity
GO:0043130 IPI ubiquitin binding
GO:0043559 IDA insulin binding
GO:0044257 IEA cellular protein catabolic process
GO:0045861 IEA negative regulation of proteolysis
GO:0046872 IEA metal ion binding
GO:0050435 IDA beta-amyloid metabolic process
GO:0051260 IDA protein homooligomerization
GO:0051289 IEA protein homotetramerization
GO:0051291 IEA protein heterooligomerization
GO:0051603 IDA proteolysis involved in cellular protein catabolic process
GO:1901142 IDA insulin metabolic process
GO:1901143 IDA insulin catabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000131070 Ide-001 protein_coding Mus_musculus 0 3814
ENSMUST00000154339 Ide-003 processed_transcript Mus_musculus 0 1901
ENSMUST00000154308 Ide-002 retained_intron Mus_musculus 0 1661
ENSMUST00000134740 Ide-005 retained_intron Mus_musculus 0 1074
ENSMUST00000150707 Ide-006 processed_transcript Mus_musculus 0 422

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