C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: fms-related tyrosine kinase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000282397 FLT1-001 ENSG00000102755 9606 - 13:28300344-28495095 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryTestisENST00000282397
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Testis
ENST00000282397 17.613±0.00 3.603±0.00 5.030±0.00 2.663±1.21 4.395±0.24 8.827±6.78 6.430±3.21 2.989±1.60 2.146±0.18 9.380±3.33 1.270±0.79 2.064±0.58 1.677±1.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000G1 CIL_0000G1_0002 CGP 13:28138506-28495128
CIL_0004CL CIL_0004CL_0001 CGP 13:28300344-28678925

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001569 IEA patterning of blood vessels
GO:0002040 IEA sprouting angiogenesis
GO:0002548 IDA monocyte chemotaxis
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004714 TAS transmembrane receptor protein tyrosine kinase activity
GO:0005021 IMP vascular endothelial growth factor-activated receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005615 TAS extracellular space
GO:0005768 IEA endosome
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0005925 IDA focal adhesion
GO:0006468 IEA protein phosphorylation
GO:0007169 TAS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284 TAS positive regulation of cell proliferation
GO:0010863 IMP positive regulation of phospholipase C activity
GO:0014068 IMP positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477 IMP cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019838 IPI growth factor binding
GO:0030154 IEA cell differentiation
GO:0030335 IDA positive regulation of cell migration
GO:0030949 IDA positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035924 IDA cellular response to vascular endothelial growth factor stimulus
GO:0036323 IDA vascular endothelial growth factor receptor-1 signaling pathway
GO:0036326 IDA VEGF-A-activated receptor activity
GO:0036327 IDA VEGF-B-activated receptor activity
GO:0036332 IDA placental growth factor-activated receptor activity
GO:0038084 IEA vascular endothelial growth factor signaling pathway
GO:0042802 IEA identical protein binding
GO:0043235 IDA receptor complex
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0043410 IDA positive regulation of MAPK cascade
GO:0043552 IMP positive regulation of phosphatidylinositol 3-kinase activity
GO:0045766 IMP positive regulation of angiogenesis
GO:0046777 IDA protein autophosphorylation
GO:0048010 IMP vascular endothelial growth factor receptor signaling pathway
GO:0048514 ISS blood vessel morphogenesis
GO:0048598 ISS embryonic morphogenesis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000031653 Flt1-001 protein_coding Mus_musculus 0 3439
ENSMUST00000110529 Flt1-002 protein_coding Mus_musculus 0 1467
ENSMUST00000031652 Flt1-003 protein_coding Mus_musculus 0 1134
ENSMUST00000125272 Flt1-005 processed_transcript Mus_musculus 0 219
ENSMUST00000142477 Flt1-004 processed_transcript Mus_musculus 3e-25 122

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