C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: sonic hedgehog
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000297261 SHH-001 ENSG00000164690 9606 - 7:155799986-155812273 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastHeartKidneyLungMuscleOvaryPlacentaTestisENST00000297261
Transcript ID Adipose Bladder Brain Breast Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000297261 0.090±0.00 0.129±0.00 0.333±0.00 0.258±0.00 0.011±0.00 0.720±0.29 0.362±0.00 0.007±0.00 0.728±0.79 0.014±0.00 0.193±0.15

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000962 CIL_000962_0001 VISTA 7:155454922-156056094
CIL_0006DC CIL_0006DC_0002 CGP 7:155644451-155812273
CIL_00026H CIL_00026H_0001 CGP 7:155799986-156677130

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0001525 IEA angiogenesis
GO:0001569 ISS patterning of blood vessels
GO:0001570 ISS vasculogenesis
GO:0001656 ISS metanephros development
GO:0001658 ISS branching involved in ureteric bud morphogenesis
GO:0001708 ISS cell fate specification
GO:0001755 ISS neural crest cell migration
GO:0001822 IEA kidney development
GO:0001942 IEA hair follicle development
GO:0001944 IEA vasculature development
GO:0001947 ISS heart looping
GO:0001948 IEA glycoprotein binding
GO:0002052 IEA positive regulation of neuroblast proliferation
GO:0002053 IEA positive regulation of mesenchymal cell proliferation
GO:0002076 IEA osteoblast development
GO:0002320 IMP lymphoid progenitor cell differentiation
GO:0003140 ISS determination of left/right asymmetry in lateral mesoderm
GO:0005113 IDA patched binding
GO:0005509 IDA calcium ion binding
GO:0005515 IPI protein binding
GO:0005539 IEA glycosaminoglycan binding
GO:0005615 ISS extracellular space
GO:0005634 IEA nucleus
GO:0005886 IEA plasma membrane
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006508 IEA proteolysis
GO:0006897 IEA endocytosis
GO:0006915 IEA apoptotic process
GO:0007154 IEA cell communication
GO:0007224 ISS smoothened signaling pathway
GO:0007228 ISS positive regulation of hh target transcription factor activity
GO:0007267 ISS:IEA cell-cell signaling
GO:0007275 IEA multicellular organismal development
GO:0007368 IEA determination of left/right symmetry
GO:0007389 ISS pattern specification process
GO:0007398 IEA ectoderm development
GO:0007405 ISS neuroblast proliferation
GO:0007411 ISS axon guidance
GO:0007417 ISS central nervous system development
GO:0007418 TAS ventral midline development
GO:0007442 IEA hindgut morphogenesis
GO:0007507 ISS heart development
GO:0007596 IEA blood coagulation
GO:0008209 ISS androgen metabolic process
GO:0008233 IEA peptidase activity
GO:0008270 IDA zinc ion binding
GO:0008283 IEA cell proliferation
GO:0008284 ISS positive regulation of cell proliferation
GO:0009790 ISS embryo development
GO:0009880 TAS embryonic pattern specification
GO:0009949 ISS polarity specification of anterior/posterior axis
GO:0009952 IEA anterior/posterior pattern specification
GO:0009953 ISS dorsal/ventral pattern formation
GO:0009986 ISS cell surface
GO:0010463 IEA mesenchymal cell proliferation
GO:0010628 IEA positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0014003 IEA oligodendrocyte development
GO:0014706 IEA striated muscle tissue development
GO:0014858 IEA positive regulation of skeletal muscle cell proliferation
GO:0014902 IEA myotube differentiation
GO:0016015 NAS morphogen activity
GO:0016020 IEA membrane
GO:0016539 IEA intein-mediated protein splicing
GO:0021513 IEA spinal cord dorsal/ventral patterning
GO:0021522 IEA spinal cord motor neuron differentiation
GO:0021794 IEA thalamus development
GO:0021904 IEA dorsal/ventral neural tube patterning
GO:0021930 ISS cerebellar granule cell precursor proliferation
GO:0021938 IEA smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021940 IEA positive regulation of cerebellar granule cell precursor proliferation
GO:0021978 IEA telencephalon regionalization
GO:0030010 IEA establishment of cell polarity
GO:0030162 ISS regulation of proteolysis
GO:0030177 IEA positive regulation of Wnt signaling pathway
GO:0030178 IEA negative regulation of Wnt signaling pathway
GO:0030323 IEA respiratory tube development
GO:0030324 ISS lung development
GO:0030326 ISS embryonic limb morphogenesis
GO:0030336 ISS negative regulation of cell migration
GO:0030539 ISS male genitalia development
GO:0030850 ISS prostate gland development
GO:0030878 IEA thyroid gland development
GO:0030900 ISS forebrain development
GO:0030901 ISS midbrain development
GO:0030902 ISS hindbrain development
GO:0031012 IEA extracellular matrix
GO:0031016 IEA pancreas development
GO:0031069 IEA hair follicle morphogenesis
GO:0032435 IEA negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033077 ISS T cell differentiation in thymus
GO:0033089 ISS positive regulation of T cell differentiation in thymus
GO:0033092 ISS positive regulation of immature T cell proliferation in thymus
GO:0034244 IEA negative regulation of transcription elongation from RNA polymerase II promoter
GO:0034504 IEA protein localization to nucleus
GO:0035115 IEA embryonic forelimb morphogenesis
GO:0035116 IEA embryonic hindlimb morphogenesis
GO:0042127 ISS regulation of cell proliferation
GO:0042130 IEA negative regulation of T cell proliferation
GO:0042177 IEA negative regulation of protein catabolic process
GO:0042307 IEA positive regulation of protein import into nucleus
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042476 IEA odontogenesis
GO:0042481 ISS regulation of odontogenesis
GO:0042733 ISS embryonic digit morphogenesis
GO:0043010 IEA camera-type eye development
GO:0043066 ISS negative regulation of apoptotic process
GO:0043237 ISS laminin-1 binding
GO:0043369 IDA CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0043588 IEA skin development
GO:0045059 ISS positive thymic T cell selection
GO:0045060 ISS negative thymic T cell selection
GO:0045109 IEA intermediate filament organization
GO:0045121 ISS membrane raft
GO:0045165 IEA cell fate commitment
GO:0045445 IEA myoblast differentiation
GO:0045596 ISS negative regulation of cell differentiation
GO:0045597 IEA positive regulation of cell differentiation
GO:0045880 ISS positive regulation of smoothened signaling pathway
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046638 ISS positive regulation of alpha-beta T cell differentiation
GO:0046639 IEA negative regulation of alpha-beta T cell differentiation
GO:0048468 ISS cell development
GO:0048538 ISS thymus development
GO:0048546 IEA digestive tract morphogenesis
GO:0048557 IEA embryonic digestive tract morphogenesis
GO:0048568 IEA embryonic organ development
GO:0048589 IEA developmental growth
GO:0048598 IEA embryonic morphogenesis
GO:0048617 IEA embryonic foregut morphogenesis
GO:0048643 IEA positive regulation of skeletal muscle tissue development
GO:0048645 IEA organ formation
GO:0048646 IEA anatomical structure formation involved in morphogenesis
GO:0048663 ISS neuron fate commitment
GO:0048706 IEA embryonic skeletal system development
GO:0048709 IEA oligodendrocyte differentiation
GO:0048714 IEA positive regulation of oligodendrocyte differentiation
GO:0048754 ISS branching morphogenesis of an epithelial tube
GO:0048839 IEA inner ear development
GO:0048856 IEA anatomical structure development
GO:0048859 IEA formation of anatomical boundary
GO:0048864 ISS stem cell development
GO:0051146 IEA striated muscle cell differentiation
GO:0051155 IEA positive regulation of striated muscle cell differentiation
GO:0051781 IDA positive regulation of cell division
GO:0060020 IEA Bergmann glial cell differentiation
GO:0060021 IEA palate development
GO:0060070 IEA canonical Wnt signaling pathway
GO:0060173 IEA limb development
GO:0060174 IEA limb bud formation
GO:0060425 IEA lung morphogenesis
GO:0060428 IEA lung epithelium development
GO:0060438 IEA trachea development
GO:0060439 IEA trachea morphogenesis
GO:0060441 IEA epithelial tube branching involved in lung morphogenesis
GO:0060442 IEA branching involved in prostate gland morphogenesis
GO:0060445 IEA branching involved in salivary gland morphogenesis
GO:0060447 IEA bud outgrowth involved in lung branching
GO:0060458 IEA right lung development
GO:0060459 IEA left lung development
GO:0060463 IEA lung lobe morphogenesis
GO:0060484 IEA lung-associated mesenchyme development
GO:0060516 IEA primary prostatic bud elongation
GO:0060523 IEA prostate epithelial cord elongation
GO:0060662 IEA salivary gland cavitation
GO:0060664 IEA epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060684 IEA epithelial-mesenchymal cell signaling
GO:0060685 IEA regulation of prostatic bud formation
GO:0060738 IDA epithelial-mesenchymal signaling involved in prostate gland development
GO:0060768 IEA regulation of epithelial cell proliferation involved in prostate gland development
GO:0060769 IEA positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060782 IEA regulation of mesenchymal cell proliferation involved in prostate gland development
GO:0060783 IEA mesenchymal smoothened signaling pathway involved in prostate gland development
GO:0060840 IEA artery development
GO:0060916 IEA mesenchymal cell proliferation involved in lung development
GO:0061053 ISS somite development
GO:0061189 IDA positive regulation of sclerotome development
GO:0071285 IEA cellular response to lithium ion
GO:0072001 IEP renal system development
GO:0072136 ISS metanephric mesenchymal cell proliferation involved in metanephros development
GO:0080125 IEA multicellular structure septum development
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:0090370 ISS negative regulation of cholesterol efflux
GO:0097190 ISS apoptotic signaling pathway
GO:1900175 NAS regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:1900180 IDA regulation of protein localization to nucleus
GO:2000062 ISS negative regulation of ureter smooth muscle cell differentiation
GO:2000063 ISS positive regulation of ureter smooth muscle cell differentiation
GO:2000357 ISS negative regulation of kidney smooth muscle cell differentiation
GO:2000358 ISS positive regulation of kidney smooth muscle cell differentiation
GO:2000729 ISS positive regulation of mesenchymal cell proliferation involved in ureter development
GO:2001054 IEA negative regulation of mesenchymal cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000002708 Shh-001 protein_coding Mus_musculus 0 1164
ENSDART00000149395 shha-001 protein_coding Danio_rerio 2e-16 94

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