C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: hematopoietic cell-specific Lyn substrate 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000314583 HCLS1-001 ENSG00000180353 9606 - 3:121631399-121660911 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000314583
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000314583 47.917±0.00 76.723±0.00 0.608±0.00 5.527±4.67 10.405±6.83 4.784±3.53 10.772±0.00 12.715±8.28 9.527±6.77 14.204±9.56 1.601±0.00 23.077±19.75 61.039±7.98 2.590±1.39

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00057R CIL_00057R_0002 CGP 3:121631399-121749767

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001085 IPI RNA polymerase II transcription factor binding
GO:0003779 IEA actin binding
GO:0005515 IPI:IEA protein binding
GO:0005634 ISS nucleus
GO:0005667 IDA transcription factor complex
GO:0005737 ISS cytoplasm
GO:0005739 IEA mitochondrion
GO:0006355 TAS regulation of transcription, DNA-templated
GO:0008284 ISS positive regulation of cell proliferation
GO:0009725 ISS response to hormone
GO:0014068 IMP positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IEA membrane
GO:0017124 IEA SH3 domain binding
GO:0019901 IPI protein kinase binding
GO:0030041 IEA actin filament polymerization
GO:0030218 ISS erythrocyte differentiation
GO:0030833 IMP regulation of actin filament polymerization
GO:0030854 IMP positive regulation of granulocyte differentiation
GO:0032403 IEA protein complex binding
GO:0033138 IMP positive regulation of peptidyl-serine phosphorylation
GO:0035556 TAS intracellular signal transduction
GO:0042531 ISS positive regulation of tyrosine phosphorylation of STAT protein
GO:0042993 IMP positive regulation of transcription factor import into nucleus
GO:0045651 IEA positive regulation of macrophage differentiation
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0050731 IMP positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897 IMP positive regulation of protein kinase B signaling
GO:0071345 IMP cellular response to cytokine stimulus
GO:2000107 IMP negative regulation of leukocyte apoptotic process
GO:2000251 IC positive regulation of actin cytoskeleton reorganization

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000023531 Hcls1-001 protein_coding Mus_musculus 0 1434
ENSMUST00000164050 Hcls1-002 nonsense_mediated_decay Mus_musculus 0 628
ENSMUST00000163755 Hcls1-003 retained_intron Mus_musculus 0 329

Loading