C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: DLC1 Rho GTPase activating protein
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000316609 DLC1-003 ENSG00000164741 9606 - 8:13214575-13514765 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainColonOvaryENST00000316609
Transcript ID Brain Colon Ovary
ENST00000316609 2.728±0.00 3.648±0.00 2.422±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003VG CIL_0003VG_0001 CGP 8:12945642-13515658
CIL_000274 CIL_000274_0001 CGP 8:13083361-13568287

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001843 ISS neural tube closure
GO:0003007 ISS heart morphogenesis
GO:0005100 IMP Rho GTPase activator activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005901 IDA caveola
GO:0005925 IDA focal adhesion
GO:0006915 IDA apoptotic process
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007264 TAS small GTPase mediated signal transduction
GO:0008285 IDA negative regulation of cell proliferation
GO:0008289 IEA lipid binding
GO:0008360 IMP regulation of cell shape
GO:0021575 ISS hindbrain morphogenesis
GO:0030036 ISS actin cytoskeleton organization
GO:0030336 IMP negative regulation of cell migration
GO:0030900 ISS forebrain development
GO:0032321 IMP positive regulation of Rho GTPase activity
GO:0032956 IMP regulation of actin cytoskeleton organization
GO:0035024 IMP negative regulation of Rho protein signal transduction
GO:0035307 IDA positive regulation of protein dephosphorylation
GO:0042169 IPI SH2 domain binding
GO:0048041 ISS focal adhesion assembly
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0051497 IDA negative regulation of stress fiber assembly
GO:1900119 IDA positive regulation of execution phase of apoptosis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000179652 Dlc1-008 retained_intron Mus_musculus 0 538
ENSMUST00000178717 Dlc1-007 retained_intron Mus_musculus 0 538
ENSMUST00000036104 Dlc1-006 retained_intron Mus_musculus 0 538
ENSMUST00000163663 Dlc1-005 protein_coding Mus_musculus 0 538
ENSMUST00000179501 Dlc1-009 protein_coding Mus_musculus 1e-34 152

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