C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: growth factor receptor-bound protein 10
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000335866 GRB10-201 ENSG00000106070 9606 - 7:50590063-50793462 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalColonHeartKidneyLiverLungMuscleOvaryTestisENST00000335866
Transcript ID Adipose Adrenal Colon Heart Kidney Liver Lung Muscle Ovary Testis
ENST00000335866 4.286±0.00 1.500±0.00 2.821±0.00 2.463±1.56 4.045±0.00 1.016±0.00 0.852±0.05 2.630±0.00 3.247±0.00 2.468±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008P3 CIL_0008P3_0001 VISTA 7:49993452-50594868
CIL_0008XT CIL_0008XT_0001 VISTA 7:50018042-50619048
CIL_0007SD CIL_0007SD_0001 VISTA 7:50081734-50682493
CIL_00089U CIL_00089U_0001 VISTA 7:50196544-50798008
CIL_0008KL CIL_0008KL_0001 VISTA 7:50358274-50958701
CIL_0004WV CIL_0004WV_0002 CGP 7:50458436-50793462
CIL_00072I CIL_00072I_0002 CGP 7:50590063-51316818

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005158 ISS insulin receptor binding
GO:0005515 IPI protein binding
GO:0005737 TAS cytoplasm
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0007165 IEA signal transduction
GO:0008286 ISS insulin receptor signaling pathway
GO:0030178 IDA negative regulation of Wnt signaling pathway
GO:0030949 IDA positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032868 ISS response to insulin
GO:0042327 ISS positive regulation of phosphorylation
GO:0045719 ISS negative regulation of glycogen biosynthetic process
GO:0046325 ISS negative regulation of glucose import
GO:0046627 ISS negative regulation of insulin receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000109654 Grb10-009 protein_coding Mus_musculus 0 1554
ENSMUST00000093321 Grb10-005 protein_coding Mus_musculus 0 1435
ENSMUST00000109653 Grb10-004 protein_coding Mus_musculus 0 813
ENSMUST00000142877 Grb10-006 processed_transcript Mus_musculus 0 222
ENSMUST00000143386 Grb10-003 protein_coding Mus_musculus 5e-32 145
ENSMUST00000150972 Grb10-001 protein_coding Mus_musculus 5e-32 145
ENSMUST00000143915 Grb10-002 protein_coding Mus_musculus 4e-28 132

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