C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: amyloid beta (A4) precursor protein
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000346798 APP-004 ENSG00000142192 9606 - 21:25880550-26170654 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; ColonHeartLiverLungMuscleOvaryPlacentaENST00000346798
Transcript ID Colon Heart Liver Lung Muscle Ovary Placenta
ENST00000346798 41.159±0.00 39.393±0.00 18.876±0.00 32.103±25.15 5.312±1.96 45.990±25.47 92.975±10.52

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000MM CIL_0000MM_0002 CGP 21:25734570-26171128
CIL_0000RE CIL_0000RE_0001 CGP 21:25880550-26573284

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001967 IEA suckling behavior
GO:0002576 TAS platelet degranulation
GO:0003677 ISS DNA binding
GO:0004867 IDA:IEA serine-type endopeptidase inhibitor activity
GO:0005102 IPI receptor binding
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005641 IDA nuclear envelope lumen
GO:0005737 ISS cytoplasm
GO:0005768 IDA endosome
GO:0005794 ISS Golgi apparatus
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0005905 IEA coated pit
GO:0005911 IEA cell-cell junction
GO:0006378 ISS mRNA polyadenylation
GO:0006417 ISS regulation of translation
GO:0006468 ISS protein phosphorylation
GO:0006878 ISS cellular copper ion homeostasis
GO:0006897 ISS endocytosis
GO:0006979 IEA response to oxidative stress
GO:0007155 IEA cell adhesion
GO:0007176 ISS regulation of epidermal growth factor-activated receptor activity
GO:0007219 IEA Notch signaling pathway
GO:0007409 ISS axonogenesis
GO:0007596 TAS blood coagulation
GO:0007617 ISS mating behavior
GO:0007626 ISS locomotory behavior
GO:0008088 ISS axon cargo transport
GO:0008201 IEA heparin binding
GO:0008203 IEA cholesterol metabolic process
GO:0008344 ISS adult locomotory behavior
GO:0008542 ISS visual learning
GO:0009986 IDA cell surface
GO:0010468 IEA regulation of gene expression
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0010952 IEA positive regulation of peptidase activity
GO:0010971 IEA positive regulation of G2/M transition of mitotic cell cycle
GO:0016020 IEA membrane
GO:0016021 ISS:IEA integral component of membrane
GO:0016199 ISS axon midline choice point recognition
GO:0016322 ISS neuron remodeling
GO:0016358 ISS dendrite development
GO:0016504 IEA peptidase activator activity
GO:0019899 IPI enzyme binding
GO:0030134 IEA ER to Golgi transport vesicle
GO:0030168 TAS platelet activation
GO:0030198 ISS extracellular matrix organization
GO:0030424 ISS axon
GO:0030900 IEA forebrain development
GO:0031093 TAS platelet alpha granule lumen
GO:0031175 ISS neuron projection development
GO:0031410 IEA cytoplasmic vesicle
GO:0031594 IEA neuromuscular junction
GO:0033130 IPI acetylcholine receptor binding
GO:0035235 ISS ionotropic glutamate receptor signaling pathway
GO:0035253 IEA ciliary rootlet
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0040014 ISS regulation of multicellular organism growth
GO:0042802 IPI identical protein binding
GO:0043005 IEA neuron projection
GO:0043197 IDA dendritic spine
GO:0043198 IDA dendritic shaft
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043235 IDA receptor complex
GO:0043393 IEA regulation of protein binding
GO:0045087 TAS innate immune response
GO:0045121 IDA membrane raft
GO:0045177 IEA apical part of cell
GO:0045202 IDA synapse
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045931 ISS positive regulation of mitotic cell cycle
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046914 IEA transition metal ion binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048669 ISS collateral sprouting in absence of injury
GO:0050803 ISS regulation of synapse structure and activity
GO:0050885 IEA neuromuscular process controlling balance
GO:0051124 IEA synaptic growth at neuromuscular junction
GO:0051233 IEA spindle midzone
GO:0051402 IMP neuron apoptotic process
GO:0051425 IPI PTB domain binding
GO:0051563 IEA smooth endoplasmic reticulum calcium ion homeostasis
GO:0070062 IDA extracellular vesicular exosome
GO:0070851 IEA growth factor receptor binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000005406 App-201 protein_coding Mus_musculus 0 2468

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