C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: SHC (Src homology 2 domain containing) transforming protein 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000368445 SHC1-001 ENSG00000160691 9606 - 1:154962298-154970741 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000368445
Transcript ID Adipose Adrenal Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000368445 21.523±0.00 30.527±0.00 6.426±4.40 14.677±0.00 3.341±0.00 7.997±0.00 8.562±0.00 30.226±0.00 15.909±0.90 11.113±2.65 6.555±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 IDA MAPK cascade
GO:0000187 IDA activation of MAPK activity
GO:0001525 IEA angiogenesis
GO:0004713 TAS protein tyrosine kinase activity
GO:0005068 TAS transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005154 ISS epidermal growth factor receptor binding
GO:0005158 IPI insulin receptor binding
GO:0005159 IPI insulin-like growth factor receptor binding
GO:0005168 IPI neurotrophin TRKA receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005543 TAS phospholipid binding
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006987 TAS activation of signaling protein activity involved in unfolded protein response
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007176 TAS regulation of epidermal growth factor-activated receptor activity
GO:0007265 TAS Ras protein signal transduction
GO:0007596 TAS blood coagulation
GO:0008284 NAS positive regulation of cell proliferation
GO:0008286 ISS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0018108 TAS peptidyl-tyrosine phosphorylation
GO:0030168 TAS platelet activation
GO:0030968 TAS endoplasmic reticulum unfolded protein response
GO:0030971 IEA receptor tyrosine kinase binding
GO:0035556 IEA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0040008 IEA regulation of growth
GO:0044267 TAS cellular protein metabolic process
GO:0045087 TAS innate immune response
GO:0045740 ISS positive regulation of DNA replication
GO:0046875 IPI ephrin receptor binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050900 TAS leukocyte migration
GO:0070435 ISS Shc-EGFR complex

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000094378 Shc1-002 protein_coding Mus_musculus 0 2495
ENSMUST00000191485 Shc1-201 protein_coding Mus_musculus 0 1925
ENSMUST00000107417 Shc1-003 protein_coding Mus_musculus 0 1925
ENSMUST00000039110 Shc1-001 protein_coding Mus_musculus 0 1925
ENSMUST00000137793 Shc1-008 protein_coding Mus_musculus 0 1131
ENSMUST00000153334 Shc1-004 retained_intron Mus_musculus 0 845
ENSMUST00000146306 Shc1-009 processed_transcript Mus_musculus 0 804
ENSMUST00000125036 Shc1-005 protein_coding Mus_musculus 0 725
ENSMUST00000128238 Shc1-007 protein_coding Mus_musculus 0 628
ENSMUST00000154791 Shc1-006 protein_coding Mus_musculus 0 462

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