C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: SHC (Src homology 2 domain containing) transforming protein 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000368453 SHC1-006 ENSG00000160691 9606 - 1:154962298-154974376 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000368453
Transcript ID Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000368453 25.798±0.00 4.951±0.00 10.761±6.23 8.500±3.75 5.512±4.52 13.179±8.43 12.289±8.32 26.555±0.00 12.516±0.00 15.678±8.01 26.480±3.84 9.115±4.87

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 IDA MAPK cascade
GO:0000187 IDA activation of MAPK activity
GO:0004713 TAS protein tyrosine kinase activity
GO:0005068 TAS transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005154 ISS epidermal growth factor receptor binding
GO:0005158 IPI insulin receptor binding
GO:0005159 IPI insulin-like growth factor receptor binding
GO:0005168 IPI neurotrophin TRKA receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005543 TAS phospholipid binding
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006987 TAS activation of signaling protein activity involved in unfolded protein response
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007176 TAS regulation of epidermal growth factor-activated receptor activity
GO:0007265 TAS Ras protein signal transduction
GO:0007596 TAS blood coagulation
GO:0008284 NAS positive regulation of cell proliferation
GO:0008286 ISS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0018108 TAS peptidyl-tyrosine phosphorylation
GO:0030168 TAS platelet activation
GO:0030968 TAS endoplasmic reticulum unfolded protein response
GO:0035556 IEA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0040008 IEA regulation of growth
GO:0044267 TAS cellular protein metabolic process
GO:0045087 TAS innate immune response
GO:0045740 ISS positive regulation of DNA replication
GO:0046875 IPI ephrin receptor binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050900 TAS leukocyte migration
GO:0070435 ISS Shc-EGFR complex

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000191485 Shc1-201 protein_coding Mus_musculus 0 2052
ENSMUST00000039110 Shc1-001 protein_coding Mus_musculus 0 2052
ENSMUST00000107417 Shc1-003 protein_coding Mus_musculus 0 2032
ENSMUST00000094378 Shc1-002 protein_coding Mus_musculus 0 1916
ENSMUST00000137793 Shc1-008 protein_coding Mus_musculus 0 1129
ENSMUST00000146306 Shc1-009 processed_transcript Mus_musculus 0 797
ENSMUST00000128238 Shc1-007 protein_coding Mus_musculus 0 745
ENSMUST00000125036 Shc1-005 protein_coding Mus_musculus 0 725
ENSMUST00000154791 Shc1-006 protein_coding Mus_musculus 0 599
ENSMUST00000153334 Shc1-004 retained_intron Mus_musculus 0 357

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