C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: methylenetetrahydrofolate reductase (NAD(P)H)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000376592 MTHFR-001 ENSG00000177000 9606 - 1:11785723-11803245 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainOvaryPlacentaTestisENST00000376592
Transcript ID Adipose Adrenal Brain Ovary Placenta Testis
ENST00000376592 2.489±0.00 3.790±0.00 3.020±0.00 5.082±0.84 0.712±0.28 3.492±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00087H CIL_00087H_0001 VISTA 1:11580820-12184055

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0004489 IEA:TAS methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0005829 TAS cytosol
GO:0006520 TAS cellular amino acid metabolic process
GO:0006555 IEA methionine metabolic process
GO:0006766 TAS vitamin metabolic process
GO:0006767 TAS water-soluble vitamin metabolic process
GO:0008015 TAS blood circulation
GO:0009086 IEA methionine biosynthetic process
GO:0033274 IEA response to vitamin B2
GO:0035999 IEA tetrahydrofolate interconversion
GO:0042493 IEA response to drug
GO:0043005 IEA neuron projection
GO:0043200 IEA response to amino acid
GO:0044281 TAS small molecule metabolic process
GO:0046500 IEA S-adenosylmethionine metabolic process
GO:0046653 IEA tetrahydrofolate metabolic process
GO:0046655 TAS folic acid metabolic process
GO:0050660 IEA flavin adenine dinucleotide binding
GO:0050661 IEA NADP binding
GO:0050667 IDA homocysteine metabolic process
GO:0051593 IEA response to folic acid
GO:0055114 IEA oxidation-reduction process
GO:0070555 IEA response to interleukin-1
GO:0072341 IDA modified amino acid binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000152498 Mthfr-005 nonsense_mediated_decay Mus_musculus 0 2231
ENSMUST00000069604 Mthfr-001 protein_coding Mus_musculus 0 2231
ENSMUST00000097788 Mthfr-003 protein_coding Mus_musculus 0 2228
ENSMUST00000141283 Mthfr-002 protein_coding Mus_musculus 0 704
ENSMUST00000125978 Mthfr-007 retained_intron Mus_musculus 0 566
ENSMUST00000174153 Mthfr-ps1-001 processed_pseudogene Mus_musculus 0 542

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