C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: MET proto-oncogene, receptor tyrosine kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000397752 MET-002 ENSG00000105976 9606 + 7:116672392-116798386 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000397752
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000397752 4.872±0.00 0.551±0.00 2.893±0.00 1.980±1.02 2.761±1.43 1.463±0.00 1.316±0.00 3.086±0.67 1.849±0.00 1.567±0.37 8.432±6.53 6.922±0.79 1.329±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00063L CIL_00063L_0002 CGP 7:116524785-116798386
CIL_00040Q CIL_00040Q_0001 CGP 7:116672390-116922049

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001886 IDA endothelial cell morphogenesis
GO:0004672 IEA protein kinase activity
GO:0004713 NAS:IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0004872 IEA receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005576 IEA extracellular region
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007165 TAS signal transduction
GO:0007166 NAS cell surface receptor signaling pathway
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 IEA multicellular organismal development
GO:0007411 TAS axon guidance
GO:0008283 TAS cell proliferation
GO:0009925 IDA basal plasma membrane
GO:0009986 IDA cell surface
GO:0016020 IEA membrane
GO:0016021 NAS:IEA integral component of membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019903 IPI protein phosphatase binding
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048754 IMP branching morphogenesis of an epithelial tube
GO:0050918 IDA positive chemotaxis
GO:0071526 IDA semaphorin-plexin signaling pathway
GO:1901299 IMP negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2001028 IMP positive regulation of endothelial cell chemotaxis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000115442 Met-003 protein_coding Mus_musculus 0 4571
ENSMUST00000115443 Met-001 protein_coding Mus_musculus 0 4543
ENSMUST00000080469 Met-201 protein_coding Mus_musculus 0 4538
ENSMUST00000145473 Met-002 retained_intron Mus_musculus 0 2652
ENSMUST00000152802 Met-006 protein_coding Mus_musculus 0 630
ENSMUST00000140070 Met-004 protein_coding Mus_musculus 0 544
ENSMUST00000148903 Met-005 protein_coding Mus_musculus 0 255

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