C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: SMAD family member 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000398417 SMAD4-001 ENSG00000141646 9606 + 18:51029614-51085045 protein_coding

Homo sapiens EnsemblGRCh38

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Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; TestisENST00000398417
Transcript ID Testis
ENST00000398417 2.095±0.47

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0000987 IDA core promoter proximal region sequence-specific DNA binding
GO:0000988 IDA protein binding transcription factor activity
GO:0001666 IMP response to hypoxia
GO:0003677 IDA DNA binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IPI:IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0006351 TAS transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0007179 IDA:IEA transforming growth factor beta receptor signaling pathway
GO:0007183 IDA SMAD protein complex assembly
GO:0010467 TAS gene expression
GO:0010718 ISS positive regulation of epithelial to mesenchymal transition
GO:0010862 ISS positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0017015 IMP regulation of transforming growth factor beta receptor signaling pathway
GO:0030308 IDA negative regulation of cell growth
GO:0030509 IDA BMP signaling pathway
GO:0030511 IDA positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030513 IMP positive regulation of BMP signaling pathway
GO:0030616 IDA transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
GO:0032444 IDA activin responsive factor complex
GO:0032909 IMP regulation of transforming growth factor beta2 production
GO:0035556 IDA intracellular signal transduction
GO:0042177 IMP negative regulation of protein catabolic process
GO:0042802 IPI identical protein binding
GO:0042803 IPI protein homodimerization activity
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0060021 ISS palate development
GO:0060391 ISS positive regulation of SMAD protein import into nucleus
GO:0060395 IDA SMAD protein signal transduction
GO:0070411 IPI I-SMAD binding
GO:0070412 IPI R-SMAD binding
GO:0071141 IDA SMAD protein complex
GO:0071559 IDA response to transforming growth factor beta

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000114939 Smad4-002 protein_coding Mus_musculus 0 2551
ENSMUST00000025393 Smad4-001 protein_coding Mus_musculus 0 2551
ENSMUST00000142672 Smad4-005 processed_transcript Mus_musculus 0 693
ENSMUST00000129326 Smad4-003 processed_transcript Mus_musculus 0 416
ENSMUST00000147315 Smad4-006 processed_transcript Mus_musculus 3e-27 130

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